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Merck

I4638

Sigma-Aldrich

Interleukin-1β Fragment 163-171 human

≥97% (HPLC), synthetic

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About This Item

Empirische Formel (Hill-System):
C39H64N12O19
CAS-Nummer:
Molekulargewicht:
1004.99
MDL-Nummer:
UNSPSC-Code:
51111800
PubChem Substanz-ID:

Biologische Quelle

synthetic

Assay

≥97% (HPLC)

Form

powder

Mol-Gew.

Mw 1004.99

Verpackung

pkg of 1 mg

Farbe

white

Löslichkeit

water: soluble 1 mg/mL, clear, colorless

UniProt-Hinterlegungsnummer

Lagertemp.

−20°C

SMILES String

CC(C)[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(O)=O

InChI

1S/C39H64N12O19/c1-17(2)31(43)38(68)47-18(6-9-25(41)53)32(62)44-15-27(55)45-19(7-10-28(56)57)33(63)46-20(8-11-29(58)59)34(64)51-24(16-52)37(67)49-22(13-26(42)54)35(65)50-23(14-30(60)61)36(66)48-21(39(69)70)5-3-4-12-40/h17-24,31,52H,3-16,40,43H2,1-2H3,(H2,41,53)(H2,42,54)(H,44,62)(H,45,55)(H,46,63)(H,47,68)(H,48,66)(H,49,67)(H,50,65)(H,51,64)(H,56,57)(H,58,59)(H,60,61)(H,69,70)/t18-,19-,20-,21-,22-,23-,24-,31-/m0/s1

InChIKey

NIXBZDOQHRZFDR-OEWCNXHOSA-N

Angaben zum Gen

human ... IL1B(3553)

Amino Acid Sequence

Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys

Biochem./physiol. Wirkung

IL1B (interleukin 1 β) is an immune-activating cytokine. In presence of infection or cell stress, it gets converted into active mature form.

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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Xianwei Wang et al.
Apoptosis : an international journal on programmed cell death, 17(8), 908-915 (2012-04-25)
Angiotensin II (Ang II) exerts its effects by activating its receptors, primarily type 1 (AT1R) and type 2 (AT2R). While the role of AT1R activation in cardiomyocyte physiology is well known, the role of AT2R in cardiomyocyte apoptosis remains controversial.
G Antoni et al.
Journal of immunology (Baltimore, Md. : 1950), 137(10), 3201-3204 (1986-11-15)
Short peptide fragments of human and murine interleukin 1 (IL 1) were synthesized on the basis of their predicted exposure on the surface of the molecule in an attempt to identify the minimal structure responsible for the immunostimulatory activity of
Gulden Avci et al.
The Journal of surgical research, 172(1), e39-e46 (2011-11-15)
Curcumin has been shown to decrease ischemia-reperfusion (I/R) injury in kidney or brain tissues. In this study, the effects of curcumin were evaluated in skeletal muscle during I/R injury. Hind limb ischemia was induced by clamping the common femoral artery
L Nencioni et al.
Journal of immunology (Baltimore, Md. : 1950), 139(3), 800-804 (1987-08-01)
The stimulating effect of a synthetic nonapeptide (fragment 163-171) of human interleukin 1 beta (IL-1 beta) on antibody responses to both T helper-dependent and T helper-independent antigens was investigated. It was shown that the nonapeptide enhanced the antibody response, as
Anna K Blakney et al.
Journal of biomedical materials research. Part A, 100(6), 1375-1386 (2012-03-13)
Poly(ethylene glycol) (PEG) hydrogels, modified with RGD, are promising platforms for cell encapsulation and tissue engineering. While these hydrogels offer tunable mechanical properties, the extent of the host response may limit their in vivo applicability. The overall objective was to

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