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GW21069

Sigma-Aldrich

Anti-CCL7 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(e):

Anti-MARC, Anti-MCP3, Anti-Monocyte chemotactic protein 3, Anti-SCYA7, Anti-Small inducible cytokine A7

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About This Item

MDL-Nummer:
MFCD01092423
UNSPSC-Code:
12352203

Biologische Quelle

chicken

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous solution

Speziesreaktivität

human

Hersteller/Markenname

Genway 15-288-21069

Methode(n)

western blot: suitable

NCBI-Hinterlegungsnummer

NP_006264.2

UniProt-Hinterlegungsnummer

P80098

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... CCL7(6354)

Immunogen

Immunogen Sequence: GI # 13435402, sequence 25-66
Recombinant chemokine (C-C motif) ligand 7

Anwendung

Anti-CCL7 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem./physiol. Wirkung

Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine, earlier called as monocyte-specific chemokine 3 (MCP3). It regulates macrophage functions. It belongs to the monocyte chemotactic protein (MCP) subfamily of the CC chemokines and is produced by astrocytes. The CCL7 gene is mapped to chromosome 17 on subbands q11.2-q12. It induces production of gelatinase B and chemotaxis of monocytes. It is often produced by tumor cell lines and regulates protease secretion by macrophages. CCL7 production may contribute to invasion and metastasis of cancer cells. It may act as a novel target metastasis of colorectal cancer (CRC) and may be of potential clinical value for the prevention of hepatic recurrences. CCL7 may have a role in vascular pathology as well.

Physikalische Form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Marcella Maddaluno et al.
Atherosclerosis, 217(1), 113-119 (2011-05-04)
Monocyte chemotactic protein-3 (MCP-3), also known as CCL7, belongs to the monocyte chemotactic protein (MCP) subfamily of the CC chemokines that includes MCP-1/CCL2, MCP-2/CCL8, MCP-4/CCL13, and MCP-5/CCL12. Few studies have examined the role of MCP-3 in vascular pathologies such as
G Opdenakker et al.
Biochemical and biophysical research communications, 191(2), 535-542 (1993-03-15)
When human MG-63 osteosarcoma cells are triggered with IL-1 beta, they produce, among various other cytokines, also monocyte chemotactic proteins (MCPs). Homogeneous MCP-1, MCP-2 and MCP-3 were found to induce production of gelatinase B and chemotaxis of monocytes. Based on
G Opdenakker et al.
Genomics, 21(2), 403-408 (1994-05-15)
Monocyte chemotactic proteins (MCPs) are chemokines involved in macrophage recruitment during inflammation and cancer. A full-size MCP-3 cDNA was used to isolate the functional human MCP-3 gene. Based on restriction analysis, subclones were selected and the MCP-3 gene sequence was
Yong Beom Cho et al.
Oncology reports, 28(2), 689-694 (2012-05-23)
The main cause of death for colorectal cancer (CRC) patients is the development of metastatic lesions at sites distant from the primary tumor. Therefore, it is important to find biomarkers that are related to the metastasis and to study the
Nicole A Renner et al.
Journal of neurovirology, 17(2), 146-152 (2011-02-01)
Monocyte/macrophages and activated lymphocytes traffic through normal brain, and this trafficking is increased in inflammatory conditions such as HIV encephalitis (HIVE). HIVE is characterized in part by perivascular accumulations of macrophages. The earliest events in this process are poorly understood

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