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G7522

3-α-Galactobiose

Name: 3-α-Galactobiose
Brand: SIGMA

synthetic, ≥90%

Synonym(e):

α-D-Gal-(1→3)-D-Gal, 3-O-α-D-Galactopyranosyl-D-galactose

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About This Item

Empirische Formel (Hill-System):

C₁₂H₂₂O₁₁

CAS-Nummer:

13168-24-6

Molekulargewicht:

342.30

Beilstein:

83008

MDL-Nummer:

MFCD00797611

UNSPSC-Code:

12352201

PubChem Substanz-ID:

24895312

Biologische Quelle

synthetic

Assay

≥90%

Lagertemp.

2-8°C

SMILES String

OC[C@H]1O[C@H](O[C@@H]2[C@@H](O)C(O)O[C@H](CO)[C@@H]2O)[C@H](O)[C@@H](O)[C@H]1O

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Analysenzertifikate (COA)

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Complete absence of the αGal xenoantigen and isoglobotrihexosylceramide in α1,3galactosyltransferase knock-out pigs.

Gisella L Puga Yung et al.

Xenotransplantation, 19(3), 196-206 (2012-06-19)

Anti-Galα1,3Galβ-R natural antibodies are responsible for hyperacute rejection in pig-to-primate xenotransplantation. Although the generation of pigs lacking the α1,3galactosyltransferase (GalT) has overcome hyperacute rejection, antibody-mediated rejection is still a problem. It is possible that other enzymes synthesize antigens similar to

[Delayed appearance of symptoms in immediate hypersensitivity: type I sensitization to galactose-α-1,3-galactose].

T Biedermann et al.

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 63 Suppl 1, 76-79 (2012-05-11)

Delayed immediate-type allergy to innards and red meat can be mediated by IgE antibodies to galactose-α-1, 3-galactose (α-Gal). Apart from humans and Old World apes, α-Gal is ubiquitously expressed in glycoproteins and glycolipids. Thus, as α-Gal is immunogenic for humans

Delayed urticaria to beef ingestion.

Henry Benjamin Coker et al.

Journal of the American Academy of Dermatology, 68(3), e101-e101 (2013-02-12)

Characterization of a new α-galactosyl-binding lectin from the mushroom Clavaria purpurea.

Beatrice Lyimo et al.

Bioscience, biotechnology, and biochemistry, 76(2), 336-342 (2012-02-09)

A galactose specific lectin (CpL) was purified from the Clavaria purpurea mushroom by affinity chromatography. CpL agglutinated only trypsin-treated rabbit erythrocytes. On enzyme linked lectin sorbent assay (ELLSA), the lectin bound with thyroglobulin and asialo bovine submaxillary mucin (BSM). The

Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation.

Darius Ghaderi et al.

Biotechnology & genetic engineering reviews, 28, 147-175 (2012-05-24)

One of the fastest growing fields in the pharmaceutical industry is the market for therapeutic glycoproteins. Today, these molecules play a major role in the treatment of various diseases, and include several protein classes, i.e., clotting factors, hormones, cytokines, antisera

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