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Merck

G6646

Sigma-Aldrich

Growth Hormone Releasing Factor rat

≥95% (HPLC), powder, synthetic

Synonym(e):

GRF

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About This Item

Empirische Formel (Hill-System):
C225H361N77O66S
CAS-Nummer:
Molekulargewicht:
5232.82
MDL-Nummer:
UNSPSC-Code:
12352200

Biologische Quelle

synthetic

Assay

≥95% (HPLC)

Form

powder

Zusammensetzung

Peptide content, ~70%

UniProt-Hinterlegungsnummer

Lagertemp.

−20°C

InChIKey

ORNDKVCWLUZAQL-FOWIMTFFSA-N

Angaben zum Gen

rat ... Ghrh(29446)

Amino Acid Sequence

His-Ala-Asp-Ala-Ile-Phe-Thr-Ser-Ser-Tyr-Arg-Arg-Ile-Leu-Gly-Gln-Leu-Tyr-Ala-Arg-Lys-Leu-Leu-His-Glu-Ile-Met-Asn-Arg-Gln-Gln-Gly-Glu-Arg-Asn-Gln-Glu-Gln-Arg-Ser-Arg-Phe-Asn

Biochem./physiol. Wirkung

Hypothalamic peptide that stimulates release of somatotropin from anterior pituitary

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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L G Frigeri et al.
Endocrinology, 122(6), 2940-2945 (1988-06-01)
Treatment of obese yellow Avy/A mice with the human GH (hGH) peptide hGH-(1-43) enhanced the in vitro sensitivity of their adipose tissue to insulin. Insulin-stimulated glucose oxidation, as determined by measurement of 14CO2 production, was enhanced 106% after administration of
J Kraicer et al.
Canadian journal of physiology and pharmacology, 69(2), 181-184 (1991-02-01)
The purpose of this study was to characterize the biological activity of the synthetic rat growth hormone releasing factor analogue rGRF(1-29)NH2 and to compare its action on growth hormone (GH) release to that of authentic rGRF(1-43)OH. We first compared the
T Audhya et al.
Proceedings of the National Academy of Sciences of the United States of America, 82(9), 2970-2974 (1985-05-01)
Polyclonal antibodies to synthetic human pancreatic growth hormone-releasing factor [hpGRF(1-44)NH2] and rat hypothalamic growth hormone-releasing factor [rhGRF(1-43)OH] were produced in rabbits by injecting these weak immunogens, coupled to thyroglobulin and emulsified with complete Freund's adjuvant in the presence of activated
N Deslauriers et al.
Regulatory peptides, 20(3), 261-271 (1988-03-01)
We studied the effect of rat growth hormone-releasing factor-(1-43) acid, rGRF(1-43)OH, on the long-term secretion of rat growth hormone (rGH) in dispersed primary cultured cells of rat anterior pituitaries over a period of 7 days or longer. Results of the
J Spiess et al.
Nature, 303(5917), 532-535 (1983-06-09)
The importance of the hypothalamus in the regulation of growth hormone (GH) secretion from the adenohypophysis has been supported by experimental and clinical evidence. It has been observed that GH secretion is in part controlled by hypothalamic GH release-inhibiting factors

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