G114

GR 73632

>97%

• Empirische Formel (Hill-System): C₄₀H₅₉N₇O₆S
• CAS-Nummer: 133156-06-6
• Molekulargewicht: 766.00
• MDL-Nummer: MFCD00144411
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 329799741
• NACRES: NA.32

Eigenschaften

• Assay: >97%
• Lagertemp.: −20°C
• SMILES String: CSCC[C@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)C(N)=O
• InChI: 1S/C40H59N7O6S/c1-27(2)24-34(38(51)44-30(36(42)49)20-23-54-4)46(3)40(53)33-18-13-22-47(33)39(52)32(26-29-16-9-6-10-17-29)45-37(50)31(25-28-14-7-5-8-15-28)43-35(48)19-11-12-21-41/h5-10,14-17,27,30-34H,11-13,18-26,41H2,1-4H3,(H2,42,49)(H,43,48)(H,44,51)(H,45,50)/t30-,31-,32-,33-,34-/m0/s1
• InChIKey: HQKPTSSZOJLFBZ-LJADHVKFSA-N
• Angaben zum Gen: human ... TAC1(6863) , TACR1(6869) ; mouse ... TAC1(21333) , TACR1(21336) ; rat ... TAC1(24806) , TACR1(24807)

Beschreibung

Amino Acid Sequence

H2N-(CH2)4-CO-Phe-Pro-NMe-Leu-Met-NH2

Allgemeine Beschreibung

Neurokinin (NK) receptors are acted upon by tachykinins or neurokinins namely, NKA and NKB. These are endogenous ligands. An exogenous agonist/ligand for NK₁ is GR 64349 petpide.

Biochem./physiol. Wirkung

GR 73632 interacts with neurokinin (NK₁) receptor, which results in rhythmic tapping of hind-foot in gerbils. Administration of this peptide in the intra-ventral tegmental area (VTA) results in locomotor activity. It interacts with and activates NK₁ receptors present on smooth muscle and interstitial cells of Cajal, resulting in elevated distention-induced peristalsis.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)