F7930

FGFR3 (397-end), active, GST tagged human

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonym(e): Eph receptor tyrosine kinase, growth hormone receptor, ACH, CD333, CEK2, HSFGFR3EX, JTK4
• NACRES: NA.32
• UNSPSC Code: 51111800
• Form: buffered aqueous glycerol solution
• Assay: ≥70% (SDS-PAGE)
• Biological source: human
• Recombinant: expressed in baculovirus infected Sf9 cells
• Mol wt: ~73 kDa

Eigenschaften

• biological source: human
• Quality Segment: 200
• recombinant: expressed in baculovirus infected Sf9 cells
• product line: PRECISIO^® Kinase
• assay: ≥70% (SDS-PAGE)
• form: buffered aqueous glycerol solution
• specific activity: 95-129 nmol/min·mg
• mol wt: ~73 kDa
• packaging: pkg of 10 μg
• technique(s): cell based assay: suitable
• solubility: water: soluble
• Protein ID accession no.: NM 000142
• UniProt accession no.: P22607
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... FGFR3(2261)

Beschreibung

General description

Research area: Cancer


FGFR3 (fibroblast growth factor receptor 3) is a receptor tyrosine kinase (RTK) and belongs to the FGFR subfamily. This subfamily includes four members namely, FGFR1, FGFR2, FGFR3, and FGFR4. It contains a ligand-binding region in its exoplasmic domain, a single transmembrane region, and a tyrosine kinase domain in its intracellular domain.FGFR3 has a strong affinity for canonical FGF ligands.

Biochem/physiol Actions

FGFR3 (fibroblast growth factor receptor 3) plays an essential role in the signaling pathways during embryogenesis and angiogenesis. This gene is either mutated or up-regulated in multiple myeloma, cervical carcinoma and nonmuscle-invasive urothelial carcinoma (UC) of the bladder.Apart from this, certain mutations in FGFR3 are also known to be linked with skeletal disorders such as various forms of dwarfism. FGFR3 also plays hepatoprotective function during liver damage.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)