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E3526

Sigma-Aldrich

Anti-phospho-Elk-1 (pSer383) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

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About This Item

MDL-Nummer:
MFCD01092332
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

200

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

buffered aqueous glycerol solution

Speziesreaktivität

rat, mouse, human

Methode(n)

western blot (chemiluminescent): 1:1,000 using Elk-1 fusion protein phosphorylated with purified Erk2

UniProt-Hinterlegungsnummer

P19419

Versandbedingung

wet ice

Lagertemp.

−20°C

Posttranslationale Modifikation Target

phosphorylation (pSer383)

Angaben zum Gen

human ... ELK1(2002)
mouse ... Elk1(13712)
rat ... Elk1(314436)

Spezifität

The antibody detects Elk-1 protein only when phosphorylated at Ser383.

Immunogen

synthetic phosphopeptide corresponding to residues around phosphorylated Ser383 of human Elk-1.

Anwendung

Anti-phospho-Elk-1 (pSer383) antibody produced in rabbit is suitable for western blotting (chemiluminescent) at a dilution of 1:1,000 using Elk-1 fusion protein phosphorylated with purified Erk2.

Biochem./physiol. Wirkung

ETS domain-containing protein Elk-1 is a protein encoded by the ELK1 gene in humans. It is a member of the Ets family of transcription factors. Elk-1 activation is important for executing its physiologic functions. Its activation is positively associated with ER and with Cyclin D1. Elk1 plays a novel role in controlling cell migration. Elk-1 is involved in a number of important cell processes through the activation of different genes in a number of normal tissues as well as in many malignancies. It is also plays a role in breast neoplasia.

Physikalische Form

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Aggelos Laliotis et al.
Breast (Edinburgh, Scotland), 22(1), 89-95 (2012-11-07)
Recently an increased interest on Elk1 protein and its role in breast cancer evolution has been noted. This protein is an element of the Ets family of transcription factors and it has been involved in a number of important cell
Rachasak Boonhok et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(25), E3519-E3528 (2016-05-18)
IFN-γ is a major regulator of immune functions and has been shown to induce liver-stage Plasmodium elimination both in vitro and in vivo. The molecular mechanism responsible for the restriction of liver-stage Plasmodium downstream of IFN-γ remains uncertain, however. Autophagy
Zaneta Odrowaz et al.
PLoS genetics, 8(5), e1002694-e1002694 (2012-05-17)
Eukaryotic transcription factors are grouped into families and, due to their similar DNA binding domains, often have the potential to bind to the same genomic regions. This can lead to redundancy at the level of DNA binding, and mechanisms are
Jacqueline F Morris et al.
Human pathology, 44(5), 766-776 (2012-11-02)
Elk-1 is a member of the Ets family of transcription factors, which are identified by a conserved Ets DNA-binding domain that mediates transcriptional regulation at Ets sequence--containing promoters. The activation domain of Elk-1 is important for executing its physiologic functions

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