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D8893

Sigma-Aldrich

Dexamethason

powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC)

Synonym(e):

(11β,16α)-9-Fluor-11,17,21-trihydroxy-16-methylpregna-1,4-dien-3,20-dion, 9α-Fluor-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadien-3,20-dion, 9α-Fluor-16α-methylprednisolon, Prednisolon F

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About This Item

Empirische Formel (Hill-System):
C22H29FO5
CAS-Nummer:
50-02-2
Molekulargewicht:
392.46
Beilstein:
2066651
EG-Nummer:
200-003-9
MDL-Nummer:
MFCD00064136
UNSPSC-Code:
12352209
PubChem Substanz-ID:
24894235
NACRES:
NA.77

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Biologische Quelle

synthetic (organic)

Qualitätsniveau

200

Sterilität

γ-irradiated

Produktlinie

BioXtra

Assay

≥80% (HPLC)

Form

powder

Wirksamkeit

4-500 ng/mL

Methode(n)

cell culture | mammalian: suitable

mp (Schmelzpunkt)

262-264 °C (lit.)

Löslichkeit

ethanol: 1 mL/vial, clear

Versandbedingung

ambient

Lagertemp.

2-8°C

SMILES String

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChIKey

UREBDLICKHMUKA-CXSFZGCWSA-N

Angaben zum Gen

human ... ABCB1(5243) , CYP3A4(1576) , IL4(3565) , IL5(3567) , NR3C1(2908)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) , Ptgs2(19225) , Tnf(21926)
rat ... Ar(24208) , Nr3c1(24413) , Tnf(24835)

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Verwandte Kategorien

Anwendung

Dexamethasone has been used as a component of osteogenic differentiation medium.[1][2][3] It has also been used to study apoptosis, cell signaling pathways and gene expression.

Biochem./physiol. Wirkung

Glucocorticoid entzündungshemmendes Mittel
Glucocorticoid entzündungshemmendes Mittel. Reguliert T-Zell-Überleben, Wachstum und Differenzierung. Hemmt die Induktion von Stickstoffmonoxid-Synthase.
Dexamethasone has immunosuppressant and antiemetic properties. It is used to treat postoperative nausea and vomiting (PONV) and chemotherapy-induced nausea and vomiting (CINV).[4] Dexamethasone plays an important role in cardiac transplant, sepsis, cancer and other pathologic disorders. It elevates the level of heat shock proteins.[5] It is an anti-inflammatory glucocorticoid with a range of effects on cell survival, cell signaling and gene expression.

Physikalische Form

powder 2-8 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

Rekonstituierung

To prepare 20 μg/ml stock solution: add 1 ml absolute ethanol; gently swirl to dissolve; add 49 ml sterile medium while mixing.

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H360FD

Gefahreneinstufungen

Repr. 1B

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Analysenzertifikate (COA)

Lot/Batch Number

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Questions

1–6 of 6 Questions  

  1. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  2. What is the solubility of Product D8893, Dexamethasone, in ethanol?

    1 answer

    1. The product is soluble in 95% ethanol (1mg/mL), yielding a clear, colorless solution. A 20 μg/mL stock solution can be formed by adding 49 mL of media to 1 mL of a 1 mg/mL ethanol stock.

      Helpful?

  3. What is the best way to dissolve Product D8893, Dexamethasone?

    1 answer

    1. The solubility of dexamethasone is <0.01 mg/mL in water and 24 mg/mL in H5784 (a 45% w/v solution of 2-hydroxypropyl-β-cyclodextrin).

      Helpful?

  4. How do the dexamethasone products D8893 and the D4902 compare?

    1 answer

    1. They are the same except for the sterility. D8893 has been g-irradiated, so it is sterile. The D4902 is not necessarily sterile. Both are cell culture tested by Sigma.

      Helpful?

  5. What is the solubility of Product D8893, Dexamethasone, in DMSO?

    1 answer

    1. The solubility of dexamethasone in DMSO is 606 mg/mL at 25°C.

      Helpful?

  6. What solution stability information do you have available for Product D8893, Dexamethasone?

    1 answer

    1. We would recommend that you store stock solutions in working aliquots frozen at -20°C. It is best to avoid repeated freeze/thaw cycles.

      Helpful?

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