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D8065

Sigma-Aldrich

Dephostatin

>98% (HPLC), solid

Synonym(e):

1,4-Dihydroxy-N-methyl-N-nitroso­aniline, 2-(Methylnitrosoamino)-1,4-benzenediol, 2-(N-methyl-N-nitroso)­hydro­quinone

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About This Item

Empirische Formel (Hill-System):
C7H8N2O3
CAS-Nummer:
151606-30-3
Molekulargewicht:
168.15
MDL-Nummer:
MFCD00467665
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278389

Assay

>98% (HPLC)

Form

solid

Farbe

light yellow

Löslichkeit

DMSO: soluble 22 mg/mL
H2O: insoluble

Versandbedingung

wet ice

Lagertemp.

−20°C

SMILES String

CN(N=O)c1cc(O)ccc1O

Angaben zum Gen

human ... PTPRCAP(5790)

Biochem./physiol. Wirkung

CD45-associated protein tyrosine phosphatase inhibitor.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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Laurent Gaté et al.
Biochemical pharmacology, 65(10), 1611-1622 (2003-05-20)
Glutathione S-transferase pi (GSTpi; EC 2.5.1.18) has been shown recently to be a regulator of mitogen-activated protein kinases (MAPK). We have developed, by chronic exposure of HL60 cells to increasing concentrations of a peptidomimetic GSTpi inhibitor TLK199, a 10-fold resistant
M Mackova et al.
Endocrinology, 141(11), 4202-4208 (2000-11-23)
Interaction between p38MAPK and p42/44MAPK in rat pinealocytes was examined by determining the effects of p38MAPK inhibitors on the phosphorylation of p42/44MAPK using Western blot analysis. Treatment with SB202190, a specific inhibitor of p38MAPK, increased p42/44MAPK phosphorylation in a concentration-dependent
Waleed El-Beialy et al.
The Journal of membrane biology, 233(1-3), 119-126 (2010-02-05)
Modulation of the physiologically influential Na(+),K(+)-ATPase is a complex process involving a wide variety of factors. To determine the possible effects of the protein tyrosine phosphatase (PTP) inhibitors dephostatin and Et-3,4-dephostatin on human and pig, renal cells and enzymatic extracts
Anna Asplund Persson et al.
European journal of pharmacology, 521(1-3), 124-132 (2005-09-27)
We examined the effects of the nitrosoamine dephostatin on the nitric oxide (NO)/cyclic guanosine 3',5'-monophosphate (cGMP)-signalling in porcine iliac arteries. Dephostatin has been characterised as a tyrosine phosphatase inhibitor, but Western blot analyses showed that dephostatin did not augment tyrosine
S Wijetunge et al.
British journal of pharmacology, 124(2), 307-316 (1998-06-26)
1. The effect of increasing cellular tyrosine phosphorylation by inhibiting endogenous tyrosine phosphatases was examined on voltage-operated calcium channel currents in vascular smooth muscle cells. 2. In single ear artery smooth muscle cells of the rabbit, studied by the whole
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