C7863

Anti-Csk antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• MDL-Nummer: MFCD01633277
• UNSPSC-Code: 12352203

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: IgG fraction of antiserum
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 50 kDa
• Speziesreaktivität: human, rat
• Methode(n): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using rat spleen; microarray: suitable; western blot: 1:2,000 using a whole cell extract of human Jurkat cell line and a cytosolic fraction of embryonic rat brain
• UniProt-Hinterlegungsnummer: P41240
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... CSK(1445) ; mouse ... Csk(12988) ; rat ... Csk(315707)

Beschreibung

Allgemeine Beschreibung

Csk is a widely expressed non-receptor tyrosine kinase that consists of a catalytic domain, as well as SH2 and SH3 domains. This kinase phosphorylates the C-terminal tail of Src-family protein tyrosine kinases (SFKs) and subsequently inhibits SFKs. As SFKs have been associated carcinogenesis, Csk may have implications in cancer therapeutics
Anti-Csk antibody is specific for human and rat Csk. The product may also react with mouse Csk. In immunoblotting, staining of Csk is specifically inhibited with the Csk immunizing peptide (rat, amino acids 433-450).

Immunogen

peptide corresponding to amino acids 433-450 at the C-terminus of rat Csk. This sequence is highly conserved in human and mouse.

Anwendung

Anti-Csk antibody is suitable for use in western blot (1:2,000 using whole cell extracts of human Jurkat cell line and cytosolic fractions of embryonic rat brain). The product may also be used for microarray and immunohistochemistry (1:200 using formalin-fixed, paraffin-embedded sections of rat spleen).

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.