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α-Cyano-4-hydroxyzimtsäure

≥98% (TLC), powder, monocarboxylic acid transport inhibitor

Synonym(e):

α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA

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Ihnen/SKUVerfügbarkeitPreis
10 g
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CHF 70.00
25 g
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CHF 147.00

Über diesen Artikel

Lineare Formel:
HOC6H4CH=C(CN)CO2H
CAS-Nummer:
Molekulargewicht:
189.17
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
248-879-1
MDL number:
Beilstein/REAXYS Number:
3271427
Assay:
≥98% (TLC)
Form:
powder

CHF 70.00


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Produktname

α-Cyano-4-hydroxyzimtsäure, ≥98% (TLC), powder

Quality Segment

assay

≥98% (TLC)

form

powder

color

yellow

mp

245-250 °C (lit.)

solubility

H2O: slightly soluble, methanol: water: soluble, polar organic solvents: soluble

storage temp.

2-8°C

SMILES string

OC(=O)\C(=C\c1ccc(O)cc1)C#N

InChI

1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+

InChI key

AFVLVVWMAFSXCK-VMPITWQZSA-N

Application

α-Cyano-4-hydroxycinnamic acid has been used to block monocarboxylate transporters.
α-Cyano-4-hydroxycinnamic acid is a useful hydrophobic matrix solution for matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Antibiotics, peptide nucleic acids (a new class of DNA mimics), and proteins with masses as high as 66,000 Da have been successfully analyzed by using this as a matrix solution.

Biochem/physiol Actions

α-Cyano-4-hydroxycinnamic acid acts as a specific inhibitor of monocarboxylic acid transport, including lactate and pyruvate transport.[1][2][3] It is also reported to block β-cell apical anion exchange (IC50 of 2.4 mM).[4]

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Dieser Artikel
C898214550539468
description

≥98% (TLC), powder

description

suitable for MALDI-TOF MS

description

97%

description

suitable for matrix substance for MALDI-MS, Ultra pure

form

powder

form

powder

form

powder

form

solid

assay

≥98% (TLC)

assay

-

assay

97%

assay

-

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: slightly soluble, polar organic solvents: soluble, methanol: water: soluble

solubility

-

solubility

methanol: soluble 50 mg/mL, clear to slightly hazy, light yellow to yellow

solubility

methanol: 10 mg/mL, clear

color

yellow

color

-

color

-

color

-


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Sens. 1B

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



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Questions

1–2 of 2 Questions  
  1. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  2. What can be used for solublization of α-Cyano-4-hydroxycinnamic acid?

    1 answer
    1. α-Cyano-4-hydroxycinnamic acid (α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA) is soluble in methanol (up to 50 mg/ml). It is also soluble at 10 mg/ml using 50% acetonitrile in 0.05% TFA for MALDI-MS. The acetonitrile concentration can be adjusted for individual preferences.For biological applications, it has been solubilized at 100 mM in DMSO or 50 mM in ethanol.

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