C1623

Anti-CLIC2 (233-247) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonym(e): Anti-CLIC2b, Anti-Chloride intracellular channel protein 2, Anti-XAP121
• UNSPSC-Code: 12352203

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: IgG fraction of antiserum
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~28 kDa
• Speziesreaktivität: human
• Methode(n): western blot: 1:500-1:2,000
• UniProt-Hinterlegungsnummer: O15247
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... CLIC2(1193)

Beschreibung

Allgemeine Beschreibung

Chloride intracellular channel protein 2 is a protein encoded by the CLIC2 gene in humans and belongs to chloride intracellular channel (CLIC) family. It is also referred as CLIC2b, MRXS32 and XAP121. CLIC2 protein is a member of the glutathione transferase class of proteins and they can exist as integral membrane-channel form or a soluble form. The gene is possibly associated with one of the many diseases linked to Xq28.

Immunogen

synthetic peptide corresponding to amino acids 233-247 of human CLIC2

Anwendung

Anti-CLIC2 (233-247) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.

Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem./physiol. Wirkung

Chloride intracellular channel 2 (CLIC2) functions by regulating ryanodine receptor (RyR) intracellular Ca(2+) release channels. RyR proteins play a major role in the regulation of Ca(2+) signaling in many cells. CLIC2 protein also helps in maintaining normal cognitive function by interacting with RyRs in the brain. In healthy individuals it is studied that the CLIC2 protein can tolerate amino acid substitutions and can be fully functional.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.