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C156

Sigma-Aldrich

D-CPT tartrate

>94%, solid

Synonym(e):

β-CPT tartrate, (–)-2β-Carbomethoxy-3β-phenyltropane tartrate, Troparil tartrate, WIN 35,065-2

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About This Item

Empirische Formel (Hill-System):
C16H21NO2 · C4H6O6
CAS-Nummer:
Molekulargewicht:
409.43
UNSPSC-Code:
12352202
PubChem Substanz-ID:
NACRES:
NA.77
Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Assay

>94%

Form

solid

Optische Aktivität

[α]22/D −95.9°, c = 1.1 in H2O(lit.)

Arzneimittelkontrolle

USDEA Schedule II; Home Office Schedule 2; regulated under CDSA - not available from Sigma-Aldrich Canada

Farbe

white

Löslichkeit

H2O: soluble
ethanol: soluble

Lagertemp.

−20°C

SMILES String

OC(C(O)C(O)=O)C(O)=O.COC(=O)[C@@H]1C2CCC(C[C@@H]1c3ccccc3)N2C

InChI

1S/C16H21NO2.C4H6O6/c1-17-12-8-9-14(17)15(16(18)19-2)13(10-12)11-6-4-3-5-7-11;5-1(3(7)8)2(6)4(9)10/h3-7,12-15H,8-10H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t12-,13+,14+,15-;/m0./s1

InChIKey

WYGLYLVLBCZESH-PEVLCXCCSA-N

Biochem./physiol. Wirkung

Binds to the cocaine receptor site on the dopamine transporter and blocks dopamine uptake.

Leistungsmerkmale und Vorteile

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Vorsicht

Hygroscopic

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Lot/Batch Number

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Potent cocaine analogs inhibit [3H]dopamine uptake in rat mesencephalic cells in primary cultures: pharmacological selectivity of embryonic cocaine sites.
Brouard, A., et al.
Brain Research, 75, 13-17 (1993)
Saturable (3H)cocaine binding in central nervous system of mouse.
M E Reith et al.
Life sciences, 27(12), 1055-1062 (1980-09-22)
M E Reith
European journal of pharmacology, 130(1-2), 65-72 (1986-10-14)
Cocaine and a cocaine analog, WIN 36,065-2, were administered daily for 3 or 4 days. Both compounds developed sensitization to their locomotor stimulatory effects, with similarly shaped dose-response curves. Dosages giving optimal sensitization were 25 mg/kg per day for cocaine
A Brouard et al.
Brain research. Developmental brain research, 75(1), 13-17 (1993-09-17)
The cellular localization of the cocaine binding sites in primary cultures of embryonic rat mesencephalic cells was previously reported to differ from that observed in adult rat brain. In order to know whether this different localization was associated with a
V V Zakusov et al.
Farmakologiia i toksikologiia, 48(1), 15-19 (1985-01-01)
The physiological action of the tropan derivative troparil (2-beta-methoxycarbonyl-3-beta-phenyltropan or 2-exo-3-exo-2-carbomethoxy-aryltropan was studied. Troparil was demonstrated to be a highly active stimulant of the nervous activity according to a lot of parameters. The drug appeared more powerful than amphetamine but

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