Binds to the cocaine receptor site on the dopamine transporter and blocks dopamine uptake.
Leistungsmerkmale und Vorteile
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Vorsicht
Hygroscopic
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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Analysenzertifikate (COA)
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Potent cocaine analogs inhibit [3H]dopamine uptake in rat mesencephalic cells in primary cultures: pharmacological selectivity of embryonic cocaine sites.
Brouard, A., et al.
Brain Research, 75, 13-17 (1993)
Saturable (3H)cocaine binding in central nervous system of mouse.
European journal of pharmacology, 130(1-2), 65-72 (1986-10-14)
Cocaine and a cocaine analog, WIN 36,065-2, were administered daily for 3 or 4 days. Both compounds developed sensitization to their locomotor stimulatory effects, with similarly shaped dose-response curves. Dosages giving optimal sensitization were 25 mg/kg per day for cocaine
The cellular localization of the cocaine binding sites in primary cultures of embryonic rat mesencephalic cells was previously reported to differ from that observed in adult rat brain. In order to know whether this different localization was associated with a
Farmakologiia i toksikologiia, 48(1), 15-19 (1985-01-01)
The physiological action of the tropan derivative troparil (2-beta-methoxycarbonyl-3-beta-phenyltropan or 2-exo-3-exo-2-carbomethoxy-aryltropan was studied. Troparil was demonstrated to be a highly active stimulant of the nervous activity according to a lot of parameters. The drug appeared more powerful than amphetamine but
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