B178

Butein

solid

• Synonym(e): (2E)- 1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-on, 2′,3,4,4′-Tetrahydroxychalkon
• Empirische Formel (Hill-System): C₁₅H₁₂O₅
• CAS-Nummer: 487-52-5
• Molekulargewicht: 272.25
• EG-Nummer: 207-659-5
• MDL-Nummer: MFCD00017300
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24891611
• NACRES: NA.77

Eigenschaften

• Form: solid
• Farbe: yellow
• Löslichkeit: DMSO: >50 mg/mL; H₂O: insoluble
• SMILES String: OC1=CC(O)=C(C(/C=C/C2=CC(O)=C(O)C=C2)=O)C=C1
• InChI: 1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+
• InChIKey: AYMYWHCQALZEGT-ORCRQEGFSA-N
• Angaben zum Gen: rat ... Alox5(25290)

Beschreibung

Allgemeine Beschreibung

Butein (2′,3,4,4′-tetrahydroxychalcone) is a chalcone and a flavonoid, that is produced in plants. It is a plant polyphenol and a bioactive constituent, that is extracted from the heartwood of Dalbergia odorifera, Caragana jubata and Rhus verniciflua stokes, and the stem bark of cashews (Semecarpus anacardium).

Biochem./physiol. Wirkung

Butein exhibit several pharmacological activities, such as anti-oxidant and anti-inflammatory activity. It stimulates apoptotic cell death of human cervical cancer cells. It has therapeutic potentials for chronic diseases, including liver tuberculosis, obesity, diabetes and hypertension. Butein can repress migration and invasion of bladder, breast and pancreatic cancer cells.

Inhibits EGFR and Src tyrosine kinase activities; inhibits cAMP-dependent PDE-IV. Induces apoptosis in B16 melanoma cells and HL-60 human leukemia cells.

Leistungsmerkmale und Vorteile

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Vorsicht

Photosensitive

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)