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B104

Sigma-Aldrich

tert-Butyl-bicyclo[2.2.2]phosphorthionat

solid

Synonym(e):

TBPS

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About This Item

Empirische Formel (Hill-System):
C8H15O3PS
CAS-Nummer:
70636-86-1
Molekulargewicht:
222.24
MDL-Nummer:
MFCD00168049
UNSPSC-Code:
12352202
PubChem Substanz-ID:
24891554
NACRES:
NA.77

Form

solid

Farbe

white to pink

Löslichkeit

DMSO: soluble
H2O: slightly soluble
ethanol: soluble

Lagertemp.

2-8°C

SMILES String

CC(C)(C)[C@@]12COP(=S)(OC1)OC2

InChI

1S/C8H15O3PS/c1-7(2,3)8-4-9-12(13,10-5-8)11-6-8/h4-6H2,1-3H3/t8-,12?

InChIKey

VTBHBNXGFPTBJL-KRDXSZEZSA-N

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Allgemeine Beschreibung

Aqueous solubility may be enhanced by the use of non-ionic detergents (Brij, Tween) or 2-hydroxypropyl-β-cyclodextrin.

Biochem./physiol. Wirkung

GABAA receptor antagonist; chloride channel blocker; extremely potent convulsant.

Leistungsmerkmale und Vorteile

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Angaben zur Herstellung

Solutions may be stored for 1-2 days at 4 °C.

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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M O Poulter et al.
Journal of neurochemistry, 68(2), 631-639 (1997-02-01)
The expression of six mRNA species (alpha 2, alpha 3, alpha 5, beta 2, beta 3, and gamma 2) encoding for GABAA receptor subunits was followed in cultured early postnatal cortical neurons by in situ hybridization histochemistry. In untreated control
Pershia Samadi et al.
Synapse (New York, N.Y.), 62(2), 101-109 (2007-11-10)
L-Dopa therapy in Parkinson's disease (PD) is counfounded by the development of involuntary movements such as L-Dopa-induced dyskinesias (LIDs). In this study GABA(A) receptor autoradiography was assessed using [(3)H]flunitrazepam binding to the benzodiazepine site of the GABA(A) receptor and [(35)S]t-butylbicyclophosphorothionate
Alex S Evers et al.
The Journal of pharmacology and experimental therapeutics, 333(2), 404-413 (2010-02-04)
In the absence of GABA, neuroactive steroids that enhance GABA-mediated currents modulate binding of [35S]t-butylbicyclophosphorothionate in a biphasic manner, with enhancement of binding at low concentrations (site NS1) and inhibition at higher concentrations (site NS2). In the current study, compound
Daniel A García et al.
European journal of pharmacology, 600(1-3), 26-31 (2008-10-22)
Thymol is a monoterpene that specifically interacts with synaptic neural functions in neuronal GABA-operated Cl(-) channels. Here we explore the effects of thymol, and propofol as positive control, on t-[(35)S]butylbicyclophosphorothionate ([(35)S]TBPS) binding in primary cultures of cortical neurons. The study
Lu-Tai Tien et al.
Neurochemical research, 32(11), 1891-1897 (2007-06-15)
Anatomical evidence indicates that gamma-aminobutyric acid (GABA)-ergic and opioidergic systems are closely linked and act on the same neurons. However, the regulatory mechanisms between GABAergic and opioidergic system have not been well characterized. In the present study, we investigated whether
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