DIABLO is known to interact with mammalian IAP homolog A (MIHA, XIAP), MIHB, MIHC and OpIAP. Furthermore, DIABLO binds to IAPs and prevents them from blocking caspases, thereby inducing apoptosis. Rabbit Anti-DIABLO antibody binds to human, bovine, pig, and canine DIABLO.
Immunogen
Synthetic peptide directed towards the C terminal region of human DIABLO
Anwendung
Rabbit Anti-DIABLO antibody can be used for western blot applications at 0.3125μg/ml.
Sequenz
Synthetic peptide located within the following region: LVKLQVEEVHQLSRKAETKLAEAQIEELRQKTQEEGEERAESEQEAYLRE
Physikalische Form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
To identify proteins that bind mammalian IAP homolog A (MIHA, also known as XIAP), we used coimmuno-precipitation and 2D immobilized pH gradient/SDS PAGE, followed by electrospray ionization tandem mass spectrometry. DIABLO (direct IAP binding protein with low pI) is a
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