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A5157

Sigma-Aldrich

DL-2-Amino-7-phosphonoheptanoic acid

~95%

Synonym(e):

AP-7

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About This Item

Empirische Formel (Hill-System):
C7H16NO5P
CAS-Nummer:
85797-13-3
Molekulargewicht:
225.18
MDL-Nummer:
MFCD00055057
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24277980

Assay

~95%

SMILES String

NC(CCCCCP(O)(O)=O)C(O)=O

InChI

1S/C7H16NO5P/c8-6(7(9)10)4-2-1-3-5-14(11,12)13/h6H,1-5,8H2,(H,9,10)(H2,11,12,13)

InChIKey

MYDMWESTDPJANS-UHFFFAOYSA-N

Angaben zum Gen

human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRINA(2907)
rat ... Grin2a(24409) , Grin2b(24410)

Biochem./physiol. Wirkung

Selective NMDA glutamate receptor antagonist; anticonvulsant.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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M K Bazil et al.
The American journal of physiology, 260(1 Pt 2), H267-H275 (1991-01-01)
These studies investigated the role of spinal N-methyl-D-aspartic acid (NMDA) receptors in the mediation of cardiovascular responses evoked by L-glutamate (L-Glu) stimulation of the rostral ventrolateral medulla (RVM). Microinjections of L-Glu into the RVM of urethan-anesthetized rats increased mean arterial
Luiz F S Souza-Pinto et al.
Pharmacology, biochemistry, and behavior, 87(2), 250-257 (2007-06-01)
It is well established that the most persistent sign of withdrawal from chronic benzodiazepine use in humans is anxiety. In contrast to other types of drugs of abuse, the emergence of this anxiety does not seem to be linked directly
M Benveniste et al.
British journal of pharmacology, 104(1), 207-221 (1991-09-01)
1. The kinetics of action of 17 structurally related NMDA receptor competitive antagonists were measured under voltage clamp in mouse hippocampal neurones. Analysis of the response to rapid changes in antagonist concentration during constant application of agonist was used to
Ariandra G Sartim et al.
Behavioural pharmacology, 30(1), 59-66 (2018-10-10)
The transient receptor potential vanilloid 1 (TRPV1) can modulate stress-related behaviours, thus representing an interesting target for new antidepressant drugs. TRPV1 can trigger glutamate release and nitric oxide synthesis in the brain, mechanisms also involved in the neurobiology of depression.
Eric C Gustafson et al.
Journal of neurophysiology, 98(1), 122-130 (2007-05-18)
We have combined electrophysiology and chemical separation and measurement techniques with capillary electrophoresis (CE) to evaluate the role of endogenous d-serine as an NMDA receptor (NMDAR) coagonist in the salamander retina. Electrophysiological experiments were carried out using whole cell recordings
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