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A2487

Sigma-Aldrich

Cotrimoxazole, Ready Made Solution

100 mg/mL in DMSO

Synonym(e):

Trimethoprim-Sulfamethoxazole, TMP-SMX

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About This Item

Empirische Formel (Hill-System):
C14H18N4O3 · 5 C10H11N3O3S
CAS-Nummer:
8064-90-2
Molekulargewicht:
1556.71
UNSPSC-Code:
51102829
NACRES:
NA.85

Form

liquid

Qualitätsniveau

200

Konzentration

100 mg/mL in DMSO

Farbe

colorless to faint yellow

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria
fungi
parasites

Wirkungsweise

DNA synthesis | interferes

Versandbedingung

dry ice

Lagertemp.

−20°C

InChI

1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)

InChIKey

WZRJTRPJURQBRM-UHFFFAOYSA-N

Anwendung

Cotrimoxazole has been used as an antimicrobial agent.

Biochem./physiol. Wirkung

Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.

Verpackung

1ml

Angaben zur Herstellung

prepared using a 1:5 mixture of trimethoprim:sulfamethoxazole

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.

Piktogramme

Health hazard
GHS08

Signalwort

Warning

H-Sätze

H361fd,H412

Gefahreneinstufungen

Aquatic Chronic 3 - Repr. 2

Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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