06563

L-Amethopterin Hydrat

≥99.0% (sum of enantiomers, HPLC)

• Synonym(e): 4-Amino-10-methylfolsäure Hydrat, L-4-Amino-N¹⁰-methylpteroylglutaminsäure Hydrat, Antifolan Hydrat, MTX Hydrat, Methotrexat Hydrat, Methylaminopterin Hydrat
• Empirische Formel (Hill-System): C₂₀H₂₂N₈O₅ · xH₂O
• CAS-Nummer: 133073-73-1
• Molekulargewicht: 454.44 (anhydrous basis)
• PubChem Substance ID: 329748247
• UNSPSC Code: 12352202
• NACRES: NA.77
• EC Number: 200-413-8
• MDL number: MFCD00150847

Eigenschaften

• biological source: synthetic
• Quality Segment: 200
• assay: ≥99.0% (sum of enantiomers, HPLC)
• form: powder or crystals
• optical activity: [α]/D +21.0±2.0°
• impurities: ≤0.1% sulfated ash
• mp: 185-204 °C
• solubility: water: insoluble
• storage temp.: −20°C
• SMILES string: [H]O[H].CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O
• InChI: 1S/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);1H2/t13-;/m0./s1
• InChI key: FPJYMUQSRFJSEW-ZOWNYOTGSA-N
• Gene Information: human ... DHFR(1719)

Beschreibung

General description

Methotrexateis an analog of folate. It shows anti-inflammatory effects throughseveral cellular mechanisms. The inhibition of dihydrofolate reductase reducesthe de novo synthesis of pyrimidines and purines, transmetylation ofphospholipids and proteins, and formation of polyamines.

Application

Potenter Inhibitor von Dihydrofolatreduktase und Mittel für Antitumor-Studien. Verwendung zur Hemmung der Dihydrofolatreduktase in DHFR-basierten Proteinexpressionssystemen.

Potenter Inhibitor von Dihydrofolatreduktase und Mittel für Antitumor-Studien. Verwendung zur Hemmung der Dihydrofolatreduktase in DHFR-basierten Proteinexpressionssystemen. Auch bei der Behandlung von pyrimethaminresistenten Plasmodium vivax-Malariaparasiten wirksam.

Potenter Inhibitor von Dihydrofolatreduktase und Mittel für Antitumor-Studien. Verwendung zur Hemmung der Dihydrofolatreduktase in DHFR-basierten Proteinexpressionssystemen. Besitzt auch immunsuppressive Wirkungen, z. B. bei rheumatoider Arthritis.

Methotrexatehydrate has been used as a disease modifyinganti-rheumatic drug (DMARD) to study its effects on Ross River virus disease (RRVD) in mice models.

Other Notes

Folic acid antagonist. Potent inhibitor of dihydrofolate reductase

Sicherheitshinweise

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301,H341,H360D,H372
• pcodes: P202 - P260 - P264 - P280 - P301 + P310 - P405
• Hazard Classifications: Acute Tox. 3 Oral - Muta. 2 - Repr. 1B - STOT RE 1
• target_organs: Liver,Bone marrow
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges