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Y0000359

Acebutolol Unreinheit B

European Pharmacopoeia (EP) Reference Standard

Synonym(e):

N-{3-Acetyl-4-{(2RS)-2-hydroxy-3-[(1-methylethyl)-amino]-propoxy}-phenyl}-acetamid, Diacetolol

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About This Item

Empirische Formel (Hill-System):
C16H24N2O4
CAS-Nummer:
Molekulargewicht:
308.37
UNSPSC-Code:
41116107
NACRES:
NA.24

Qualität

pharmaceutical primary standard

API-Familie

acebutolol

Hersteller/Markenname

EDQM

Anwendung(en)

pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-8°C

SMILES String

N(C(C)C)CC(O)COc1c(cc(cc1)NC(=O)C)C(=O)C

InChI

1S/C16H24N2O4/c1-10(2)17-8-14(21)9-22-16-6-5-13(18-12(4)20)7-15(16)11(3)19/h5-7,10,14,17,21H,8-9H2,1-4H3,(H,18,20)

InChIKey

AWOGXJOBNAWQSF-UHFFFAOYSA-N

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Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Acebutolol impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Verpackung

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Sonstige Hinweise

Sales restrictions may apply.

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Analysenzertifikate (COA)

Lot/Batch Number

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Die Dokumentenbibliothek aufrufen

High-performance liquid chromatographic determination of diacetolol enantiomers.
M Piquette-Miller et al.
Journal of chromatography, 533, 300-303 (1990-11-30)
J R Ryan
American heart journal, 109(5 Pt 2), 1131-1136 (1985-05-01)
The clinical pharmacology and pharmacokinetics of acebutolol are summarized. Acebutolol and its longer-acting metabolite, diacetolol, are rapidly absorbed into the circulation from the gastrointestinal tract, and their bioavailability, unlike that of propranolol and metoprolol, is not significantly altered by whether
B N Singh et al.
Pharmacotherapy, 6(2), 45-63 (1986-03-01)
Acebutolol is a new hydrophilic, cardioselective beta-adrenergic-blocking agent that possesses partial agonist and membrane-stabilizing activities. In the treatment of mild to moderate essential hypertension, once-daily acebutolol as monotherapy provides effective control in a large majority of patients and produces a
J Mantz et al.
Journal of cardiothoracic anesthesia, 4(5), 577-581 (1990-10-01)
Cardiopulmonary bypass (CPB) has been reported to alter the disposition of numerous drugs and consequently to modify their plasma levels. The present study was designed to delineate the time course of acebutolol (a cardioselective beta-blocker) and diacetolol (its main metabolite)
M Piquette-Miller et al.
Journal of pharmaceutical sciences, 80(4), 313-316 (1991-04-01)
The chiral beta-blocker acebutolol (AC) is marketed as a racemic mixture. Both AC and its major metabolite, diacetotol (DC), are chiral, the S-enantiomer possessing beta-blocking activity. The pharmacokinetics of AC and DC enantiomers was determined in 12 healthy subjects following

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