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SMB01344

Sigma-Aldrich

N-Methyl-4-pyridone-5-carboxamide

Synonym(e):

1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide, 1,4-Dihydro-1-methyl-4-oxo-nicotinamide, 1-Methyl-1,4-dihydro-4-oxo-3-pyridinecarboxamide, 1-Methyl-4-pyridone-3-carboxamide, 1-Methyl-4-pyridone-5-carboxamide, 4-Py, 4PY, Me4PY, Met4PY, N1-Methyl-4-pyridone-3-carboxamide, N1-Methyl-4-pyridone-5-carboxamide

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About This Item

Empirische Formel (Hill-System):
C7H8N2O2
CAS-Nummer:
769-49-3
Molekulargewicht:
152.15
MDL-Nummer:
MFCD31726263
UNSPSC-Code:
12352205
NACRES:
NA.77

Assay

≥95% (HPLC)

Qualitätsniveau

100

Form

solid

InChI

1S/C7H8N2O2/c1-9-3-2-6(10)5(4-9)7(8)11/h2-4H,1H3,(H2,8,11)

InChIKey

KTLRWTOPTKGYQY-UHFFFAOYSA-N

Allgemeine Beschreibung

N1-methyl-4-pyridone-5-carboxamide is involved in nicotinate and nicotinamide metabolism.

Anwendung

Metabolomics research

Sonstige Hinweise

For additional information on our range of Biochemicals, please complete this form.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

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Analysenzertifikate (COA)

Lot/Batch Number
MKCQ7019

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Aurélie Lenglet et al.
Toxins, 8(11) (2016-11-18)
N-methyl-2-pyridone-5-carboxamide (2PY, a major metabolite of nicotinamide, NAM) was recently identified as a uremic toxin. Recent interventional trials using NAM to treat high levels of phosphorus in end-stage renal disease have highlighted new potential uremic toxicities of 2PY. In the
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.
Yoshino, et al.
Science (New York, N.Y.), 372, 1224-1229 (2021)
Renata Novak Kujundžić et al.
International journal of molecular sciences, 22(11) (2021-06-03)
The activity of nicotinamide N-methyltransferase (NNMT) is tightly linked to the maintenance of the nicotinamide adenine dinucleotide (NAD+) level. This enzyme catalyzes methylation of nicotinamide (NAM) into methyl nicotinamide (MNAM), which is either excreted or further metabolized to N1-methyl-2-pyridone-5-carboxamide (2-PY)

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