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80073

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α-Hydroxymetoprolol

analytical standard

Synonym(e):

3-[4-(1-Hydroxy-2-methoxyethyl)-phenoxy]-1-isopropylamino-2-propanol, 4-{2-Hydroxy-3-[(1-methylethyl)-amino]-propoxy}-α-(methoxymethyl)-benzolmethanol

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About This Item

Empirische Formel (Hill-System):
C15H25NO4
CAS-Nummer:
56392-16-6
Molekulargewicht:
283.36
Beilstein:
6571082
MDL-Nummer:
MFCD00871829
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329768718
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

100

Assay

≥98.0% (HPLC)

Haltbarkeit

limited shelf life, expiry date on the label

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

mp (Schmelzpunkt)

68-74 °C

Anwendung(en)

forensics and toxicology
pharmaceutical (small molecule)

Format

neat

SMILES String

OC(CNC(C)C)COC1=CC=C(C(O)COC)C=C1

InChI

1S/C15H25NO4/c1-11(2)16-8-13(17)9-20-14-6-4-12(5-7-14)15(18)10-19-3/h4-7,11,13,15-18H,8-10H2,1-3H3

InChIKey

OFRYBPCSEMMZHR-UHFFFAOYSA-N

Verwandte Kategorien

Anwendung

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Choose from one of the most recent versions:

Analysenzertifikate (COA)

Lot/Batch Number
BCCK5317
BCCD2430
BCBV0619
BCBM2433V
BCBM2433

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S W Ellis et al.
The Biochemical journal, 316 ( Pt 2), 647-654 (1996-06-01)
Cytochrome P-450 2D6 (CYP2D6) is an important human drug-metabolizing enzyme responsible for the oxidation of more than 30 widely used therapeutic agents. The enzymes encoded by the published genomic [Kimura, Umeno, Skoda, Meyer and Gonzalez (1989) Am. J. Hum. Genet.
Carrie A Morris et al.
Antimicrobial agents and chemotherapy, 58(10), 5900-5908 (2014-07-30)
The objectives of this study were to characterize any drug-drug interaction between the antimalarial Pyramax (pyronaridine-artesunate [PA]) and the CYP2D6 probe substrate metoprolol and to assess the safety of 60-day or 90-day PA redosing, particularly with regard to liver biochemistry
K Balmér et al.
Journal of chromatography, 553(1-2), 391-397 (1991-08-16)
The two enantiomers of metoprolol and the four enantiomeric forms of alpha-hydroxymetoprolol were separated by liquid chromatography on a Chiralcel OD column containing a cellulose tris(3,5-dimethyl-phenylcarbamate) chiral stationary phase. The column efficiency was strongly dependent on the flow-rate and the
H Shimizu et al.
Arzneimittel-Forschung, 42(6), 802-806 (1992-06-01)
The maximum plasma concentrations (Cmax) after oral administration of 120 mg tablets of slow-release metoprolol (CAS 37350-58-6) to 75 Japanese healthy male volunteers and 15 arrhythmic patients were measured. Extensive and poor metabolizers after oral administrations of slow-release metoprolol tablets
D R Sohn et al.
Therapeutic drug monitoring, 14(3), 184-189 (1992-06-01)
We examined the utility of the postdose 3-h plasma metabolic ratio (MR) as a phenotyping method for assessing genetically determined debrisoquine-type oxidation polymorphism after an oral dose of 100 mg of metoprolol tartrate administered to 402 unrelated, healthy, and native
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