MABT386

Anti-Hu GBP-1/GBP-1 Antibody, clone 6C5.1

clone 6C5.1, from mouse

• Synonym(e): Interferon-induced guanylate-binding protein 1, GTP-binding protein 1, GBP-1, HuGBP-1, Guanine nucleotide-binding protein 1
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: 6C5.1, monoclonal
• Speziesreaktivität: human
• Methode(n): immunohistochemistry: suitable (paraffin); western blot: suitable
• Isotyp: IgG2aκ
• NCBI-Hinterlegungsnummer: NP_002044
• UniProt-Hinterlegungsnummer: P32455
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... GBP1(2633)

Beschreibung

Allgemeine Beschreibung

mgbp-2/hGBP-1, or also known as Interferon-induced guanylate-binding protein 1, GTP-binding protein 1 (GBP-1/HuGBP-1), or Guanine nucleotide-binding protein 1, and encoded by the gene GBP1, is another enzyme important in innate defense. Among its functions, this enzyme hydrolyzes GTP to GMP and appears to promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, thus providing broad host protection against different pathogen classes. mgbp-2/hGBP-1 is localized to the cytoplasm but is also secreted in endothelial cells and localizes to the cytoplasmic side of the Golgi apparatus in expressing most cells. Interestingly, mgbp-2/hGBP-1is secreted by the endothelial cells in the CNS upon bacterial challenge even when not induced by gamma interferon. The enzyme is also induced by TNF-alpha and IL-1beta expression by immune cells and is considered a proinflammatory response factor.

Immunogen

GST-tagged recombinant protein corresponding to hu GBP-1/GBP-1.

Anwendung

Research Category
Zellstruktur

Research Sub Category
ECM-Proteine

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected hu GBP-1/GBP-1 in human spleen tissues and rat brain tissue.

This Anti-Hu GBP-1/GBP-1 Antibody, clone 6C5.1 is validated for use in western blotting & IHC (Paraffin) for the detection of Hu GBP-1/GBP-1.

Qualität

Evaluated by Western Blotting in human spleen tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected hu GBP-1/GBP-1 in 400 µg of human spleen tissue lysate.

Zielbeschreibung

~68 kDa observed

Physikalische Form

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable