MABT107

Anti-Src-like-adapter Antibody/SLAP1, clone 1D9.1

clone 1D9.1, from mouse

• Synonym(e): Src-like-adapter, Src-like-adapter protein 1, SLAP-1, hSLAP
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 1D9.1, monoclonal
• Speziesreaktivität: human
• Methode(n): western blot: suitable
• Isotyp: IgMκ
• NCBI-Hinterlegungsnummer: NP_006739
• UniProt-Hinterlegungsnummer: Q13239
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... SLA(6503)

Beschreibung

Allgemeine Beschreibung

Src-like-adapter/SLAP1 protein, also known as SLAP, and encoded by the gene SLA/SLAP/SLAP1, is an adapter protein which negatively regulates T cell receptor signaling by inhibiting T cell antigen induced proliferation and works to control the positive selection and mitosis of T cells. SLAP1 also acts to connect signaling proteins such as ZAP70 with the T cell specific CBL ubiquitin ligase that plays a central role in degrading signaling proteins, and a critical role in limiting or initiating the T-cell specific- antigen-specific immunotolerance limits in T cells activation. Src-like-adapter/SLAP1 is localized to the cytoplasm and endosomes within cells. Src-like-adapter/SLAP1 is expressed in lung and fetal brain, and weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas. Recent research suggest that SLAP1 may also play a role in different cancers and in modulation of receptor tyrosine kinase signaling in cancers apart from its conventional role in regulation of T cell receptor stability.

Immunogen

Linear peptide corresponding to human Src-like-adapter/SLAP1.

Anwendung

Research Category
Zellstruktur

Research Sub Category
Adhäsions-Proteine (CAMs – Zelladhäsionsmoleküle)

This Anti-Src-like-adapter Antibody/SLAP1, clone 1D9.1 is validated for use in western blotting for the detection of Src-like-adapter/SLAP1.

Qualität

Evaluated by Western Blotting in Human Lung tissue lysate.

Western Blotting Analysis: A 1:5,000 dilution of this antibody detected Src-like-adapter/SLAP1 in 400 µg of human lung tissue lysate.

Zielbeschreibung

~38 kDa observed. The calculated molecular weight of this protein is 32 kDa; however, it may be observed at higher molecular weights due to known Post-translational modification sites.

Physikalische Form

Format: Purified

Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable