MAB4147
Anti-MRP1 Antibody, clone MRPm5
clone MRPm5, Chemicon®, from mouse
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About This Item
UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Empfohlene Produkte
Biologische Quelle
mouse
Qualitätsniveau
Antikörperform
tissue culture supernatant
Antikörper-Produkttyp
primary antibodies
Klon
MRPm5, monoclonal
Speziesreaktivität
human
Hersteller/Markenname
Chemicon®
Methode(n)
flow cytometry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
Isotyp
IgG2a
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Angaben zum Gen
human ... ABCC1(4363)
Verwandte Kategorien
Spezifität
This antibody reacts with an internal epitope of MRP1, a 180-195 kDa transmembrane transporter protein overexpressed in various human non-P-glycoprotein MDR tumor cell lines. The antibody does not cross-react with the human MDR1 and MDR3 gene products.
Immunogen
Bacterial fusion protein of MRP1 containing amino acids 986-1204 of the protein.
Anwendung
Research Category
Stoffwechsel
Stoffwechsel
Research Sub Category
Toxikologie & Arzneimittelresistenz
Toxikologie & Arzneimittelresistenz
Detect MRP1 using this Anti-MRP1 Antibody, clone MRPm5 validated for use in FC, WB, IH, IH(P).
Western blotting
Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections or paraffin-embedded tissue sections
Flow Cytometry
Optimal working dilutions must be determined by end user.
Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections or paraffin-embedded tissue sections
Flow Cytometry
Optimal working dilutions must be determined by end user.
Physikalische Form
Format: Purified
Purified from tissue culture supernatant, serum-free. Liquid containing 0.7% BSA and 0.1% sodium azide.
Lagerung und Haltbarkeit
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. May be stored at 2-8°C for short term use. Avoid repeated freeze-thaw cycles.
Sonstige Hinweise
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Rechtliche Hinweise
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 2
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Expression of the multidrug resistance-associated protein (MRP) gene in primary non-small-cell lung cancer.
Nooter, K, et al.
Annals of Oncology, 7, 75-81 (1996)
Prognostic significance of the immunohistochemical expression of O(6)-methylguanine-DNA methyltransferase, P-glycoprotein, and multidrug resistance protein-1 in glioblastomas.
Takao Nakagawa, Kazunori Ido, Takahiro Sakuma, Hiroaki Takeuchi, Kazufumi Sato et al.
Neuropathology : Official Journal of the Japanese Society of Neuropathology null
Zhongxing Liang et al.
Pharmaceutical research, 28(12), 3091-3100 (2011-08-20)
To explore whether miR-19 is involved in the regulation of multidrug resistance (MDR), one of the main causes of breast cancer mortality, and modulates sensitivity of tumor cells to chemotherapeutic agents. We analyzed miRNA expression levels in three MDR cell
Tissue distribution of the multidrug resistance protein.
Flens, M J, et al.
The American Journal of Pathology, 148, 1237-1247 (1996)
Zhongxing Liang et al.
Biochemical pharmacology, 79(6), 817-824 (2009-11-04)
Multidrug resistance-associated protein (MRP-1/ABCC1) transports a wide range of therapeutic agents and may play a critical role in the development of multidrug resistance (MDR) in tumor cells. However, the regulation of MRP-1 remains controversial. To explore whether miRNAs are involved
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