MAB1820

Anti-Scribble Antibody

clone 7C6.D10, Chemicon^®, from mouse

• Synonym(e): Scrib, LAP4
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: 7C6.D10, monoclonal
• Speziesreaktivität: human
• Hersteller/Markenname: Chemicon^®
• Methode(n): western blot: suitable
• Isotyp: IgG1κ
• GenBank-Hinterlegungsnummer: AAL38976
• UniProt-Hinterlegungsnummer: Q14160
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... SCRIB(23513)

Beschreibung

Allgemeine Beschreibung

Scribble is a tumor suppressor marker first discovered in Drosophila that has been implicated in the control of cell proliferation, polarity, invasion, and metastasis (Humbert, et al, 2003). Mammalian Scribble expresses basolateral staining in epithelial tissue and highly polarized expression in T lymphocytes (Dow, et al, 2003) (Ludford-Menting, et al, 2005), and plays an essential role in the regulation of the polarity specifically involved in directed epithelial migration. Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear (Dow, et al, 2007).

Spezifität

Predicted to cross react with mouse based on sequence homology. Reactivity with other species has not been tested.

Immunogen

Epitope: PDZ2 domain of Scribble

GST-tagged fusion protein corresponding to the PDZ2 domain of Scribble

Anwendung

Research Sub Category
Tumormarker

Cytoskelett

Suggested dilutions:
Western blot: 0.2 µg (1:2000)

This Anti-Scribble Antibody is validated for use in WB for the detection of Scribble.

Qualität

Routinely evaluated by Western blot on HeLa cell lysates.

Zielbeschreibung

220 kDa

Physikalische Form

Format: Purified

Purified in PBS containing with 0.05% NaN3.

Lagerung und Haltbarkeit

Maintain at 2-8°C for up to 1 year after date of receipt.

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

GenBank is a registered trademark of United States Department of Health and Human Services

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable