AG340

Epithelial Sodium Channel γ, control peptide for AB3534P

• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Konzentration: 1 mg/mL
• Qualitätsniveau: 300
• Methode(n): cell based assay: suitable
• UniProt-Hinterlegungsnummer: P51170
• Angaben zum Gen: rat ... SCNN1G(24768)

Beschreibung

Allgemeine Beschreibung

FUNCTION: SwissProt: P51170 # Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
SIZE: 649 amino acids; 74270 Da
SUBUNIT: Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2.
SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein. Note=Apical membrane of epithelial cells.
PTM: Phosphorylated on serine and threonine residues (By similarity). & Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation (By similarity).
DISEASE: SwissProt: P51170 # Defects in SCNN1G are a cause of Liddle syndrome [MIM:177200]. It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel.
SIMILARITY: SwissProt: P51170 ## Belongs to the amiloride-sensitive sodium channel family.

Anwendung

Antibody blocking (AB3534P)

ELISA

Optimal working dilution must be determined by the end user.

Physikalische Form

Liquid in PBS pH 7.4, containing 0.1% sodium azide.

Lagerung und Haltbarkeit

Store at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids