ABC848

Anti-Toso Antibody

from rabbit, purified by affinity chromatography

• Synonym(e): Fas apoptotic inhibitory molecule 3, Regulator of Fas-induced apoptosis Toso, Toso
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Aufgereinigt durch: affinity chromatography
• Speziesreaktivität: human
• Methode(n): western blot: suitable
• UniProt-Hinterlegungsnummer: O60667
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... FAIM3(9214)

Beschreibung

Allgemeine Beschreibung

Apoptosis is an important process by which normal tissue homeostasis and function are maintained. Toso (also known as Fas apoptotic inhibitory molecule 3, Regulator of Fas-induced apoptosis and FAIM3) is a novel regulator of Fas-induced apoptosis in lymphoid cells and when overexpressed in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.

Immunogen

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to a 13 amino acid peptide near the C-terminus of human Toso.

Anwendung

Research Category
Apoptose & Krebs

Research Sub Category
Apoptose - Weiterführende Produkte

Anti-Toso Antibody is a highly specific rabbit polyclonal antibody, that targets Fas apoptotic inhibitory molecule 3 & has been tested in western blotting.

Qualität

Evaluated by Western Blotting in human lung tissue lysate with and without blocking peptide.

Western Blotting Analysis: 1 μg/mL of this antibody detected Toso in human lung tissue lysate with and without blocking peptide.

Zielbeschreibung

~60 kDa observed.
Despite its predicted molecular weight of 43 kDa, Toso often migrates at 60 kDa in western blots.
Uncharacterized bands may be observed in some lysate(s).

Physikalische Form

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable