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Merck
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Dokumente

AB9682

Sigma-Aldrich

Anti-Dardarin Antibody

serum, Chemicon®

Synonym(e):

LRRK2 Leucine-rich repeat kinase 2

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100

Antikörperform

serum

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Speziesreaktivität

mouse, human

Hersteller/Markenname

Chemicon®

Methode(n)

ELISA: suitable
western blot: suitable

Isotyp

IgG

NCBI-Hinterlegungsnummer

NM_198578.2

UniProt-Hinterlegungsnummer

Q5S007

Versandbedingung

dry ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... LRRK2(120892)

Spezifität

Recognizes LRRK2 [leucine-rich repeat kinase 2, Dardarin]. By Western blot the antibody recognizes a band at ~240 kDa in mouse brain extract. An additional band at ~130-140 kDa can also be seen. On human brain lysate the antibody recognizes a band at ~150 kDa.

Immunogen

Synthetic peptide from rat LRRK2.

Anwendung

Research Category
Neurowissenschaft
Research Sub Category
Neurodegenerative Krankheiten
Anti-Dardarin Antibody detects level of Dardarin & has been published & validated for use in ELISA & WB.
Western blot: 1:5,000-1:10,000 on mouse brain extract.

Optimal working dilutions must be determined by the end user.

Zielbeschreibung

286 kDa

Physikalische Form

Unpurified
Rabbit Serum. Liquid.

Lagerung und Haltbarkeit

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hinweis zur Analyse

Control
Brain tissue

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Izabella D Greene et al.
Journal of neuroscience research, 92(4), 506-516 (2014-01-01)
Mutations in the leucine-rich repeat kinase 2 (lrrk2) gene are the leading genetic cause of Parkinson's disease (PD). In characterizing the novel ROC domain mutant A1442P, we compared its steady-state protein levels, propensity to aggregate, and toxicity with the pathogenic
Berta Pons et al.
Oncology reports, 27(1), 225-231 (2011-09-17)
Translational control is a crucial component of cancer development and progression. Eukaryotic initiation factor (eIF) 4E mediates eIF4F association with the mRNA
Saskia Biskup et al.
BMC neuroscience, 8, 102-102 (2007-11-30)
Mutations within the leucine-rich repeat kinase 2 (LRRK2) gene account for a significant proportion of autosomal-dominant and some late-onset sporadic Parkinson's disease. Elucidation of LRRK2 protein function in health and disease provides an opportunity for deciphering molecular pathways important in

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