565792-M

γ-Secretase Inhibitor XXIII, Aβ42-Selective

The γ-Secretase Inhibitor XXIII, Aβ42-Selective controls the biological activity of γ-Secretase.

• Synonym(e): γ-Secretase Inhibitor XXIII, Aβ42-Selective
• Empirische Formel (Hill-System): C₃₀H₃₉N₇O
• Molekulargewicht: 513.68
• UNSPSC-Code: 12352203

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: beige
• Löslichkeit: DMSO: 25 mg/mL
• Lagertemp.: 2-8°C

Beschreibung

Allgemeine Beschreibung

A cell-permeable purine compound that acts as a highly potent and selective inhibitor against γ-secretase-mediated production of Aβ42 over Aβ40 (IC₅₀ = 21 and 350 nM, respectively) and Notch1 (Notch IC₅₀/ Aβ42 IC₅₀ >2400) in cultures in vitro. Reported to be blood-brain barrier-permeant and orally bioavailable in APP-YAC transgenic mice and effectively reduce Aβ42 (by 73%), but not Aβ40, level in brain (100 mg/kg, p.o.) in vivo.

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Sonstige Hinweise

Rivkin, A., et al. 2010. Bioorg. Med. Chem. Lett.20, 2279.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable