368056

Granzyme B Inhibitor IV

The Granzyme B Inhibitor IV controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

• Synonym(e): Granzyme B Inhibitor IV, Ac-IEPD-CHO, Caspase-8 inhibitor III
• Empirische Formel (Hill-System): C₂₂H₃₄N₄O₉
• Molekulargewicht: 498.53
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze
• Farbe: white
• Löslichkeit: DMSO: 5 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

A reversible inhibitor of Granzyme B that also inhibits caspase-8. Granzyme B is a protease involved in the induction of rapid target cell death by cytotoxic lymphocytes.

A reversible inhibitor of granzyme B and caspase-8.

Biochem./physiol. Wirkung

Cell permeable: no

Primary Target
granzyme B

Product does not compete with ATP.

Reversible: yes

Warnhinweis

Toxicity: Standard Handling (A)

Sequenz

Ac-Ile-Glu-Pro-Asp-CHO

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Harris, J.L., et al. 1998. J. Biol. Chem. 273, 27364.
Thornberry, N.A., et al. 1997. J. Biol. Chem.272, 17907.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable