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05-827

Sigma-Aldrich

Anti-Glucocorticoid Receptor Antibody, clone FIGR

clone FIGR, Upstate®, from mouse

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Antikörperform

purified antibody

Antikörper-Produkttyp

primary antibodies

Klon

FIGR, monoclonal

Speziesreaktivität

hamster, mouse, rat

Darf nicht reagieren mit

human

Hersteller/Markenname

Upstate®

Methode(n)

immunoprecipitation (IP): suitable
western blot: suitable

Isotyp

IgG2b

NCBI-Hinterlegungsnummer

NM_000176

UniProt-Hinterlegungsnummer

P04150

Versandbedingung

dry ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... NR3C1(2908)

Spezifität

glucocorticoid receptor

Immunogen

Native glucocorticoid receptor purified from rat liver

Anwendung

Research Category
Epigenetik & nukleäre Funktionen
Research Sub Category
Transkriptionsfaktoren
Detect Glucocorticoid Receptor with Anti-Glucocorticoid Receptor Antibody, clone FIGR (Mouse Monoclonal Antibody), that has been shown to work in IP & WB.

Qualität

routinely evaluated by immunoblot on RIPA lysates from L6, PC12, and 3T3/A31 cells.

Zielbeschreibung

85-100kDa

Physikalische Form

Protein G Purified
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified

Lagerung und Haltbarkeit

2 years at -20°C

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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R C Kaltreider et al.
Environmental health perspectives, 109(3), 245-251 (2001-05-03)
Chronic human exposure to nonovertly toxic doses of arsenic is associated with an increased risk of cancer. Although its carcinogenic mechanism is still unknown, arsenic does not directly cause DNA damage or mutations and is therefore thought to act principally
J E Bodwell et al.
The Journal of biological chemistry, 266(12), 7549-7555 (1991-04-25)
Glucocorticoid receptors in vivo are phosphorylated in the absence of hormone and become hyperphosphorylated in the presence of glucocorticoid agonist but not antagonists (Ortí, E., Mendel, D.B., Smith, L.I., and Munck, A. (1989) J. Biol. Chem. 264, 9728-9731). As a
J Richardson et al.
Molecular endocrinology (Baltimore, Md.), 13(4), 546-554 (1999-04-09)
The glutamate synthetase gene (GS) contains a composite glucocorticoid response element (cGRE) comprised of a GRE and an adjacent element with features of both a cAMP-response element (CRE) and a 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE). The CRE/TRE element of
Arman Nayebosadri et al.
American journal of physiology. Cell physiology, 305(3), C309-C322 (2013-05-25)
The lamina serves to maintain the nuclear structure and stiffness while acting as a scaffold for heterochromatin and many transcriptional proteins. Its role in endothelial mechanotransduction, specifically how nuclear mechanics impact gene regulation under shear stress, is not fully understood.

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