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Anti-ZAP-70 Antibody, clone 1E7.2

clone 1E7.2, Upstate®, from mouse

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

100

Antikörperform

purified antibody

Antikörper-Produkttyp

primary antibodies

Klon

1E7.2, monoclonal

Speziesreaktivität

human, mouse

Hersteller/Markenname

Upstate®

Methode(n)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotyp

IgG1

NCBI-Hinterlegungsnummer

NM_001079

UniProt-Hinterlegungsnummer

P43403

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

mouse ... Ppp1Ca(19045)

Allgemeine Beschreibung

Note: This product is for in vitro research use only. It is not to be used for commercial purposes. Use of this product to produce products for sale or for diagnostic, therapeutic or drug discovery purposes is prohibited. In order to obtain a license to use this product for commercial purposes, contact The Regents of the University of California

Spezifität

Zap-70

Immunogen

GST fusion protein between the second SH2 domain and precedes the kinase domain corresponding to residues 282-307 of human ZAP-70

Anwendung

Research Category
Zelluläre Signaltransduktion
Research Sub Category
Immunologische Signalübertragung
Anti-ZAP-70 Antibody, clone 1E7.2 is an antibody against ZAP-70 for use in IC, IP & WB.

Qualität

routinely evaluated by immunoblot on RIPA lysates from Jurkat cells

Zielbeschreibung

Mr ~70kDa

Physikalische Form

Protein G Purified
Format: Purified
of 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%

Lagerung und Haltbarkeit

2 years at -20°C

Hinweis zur Analyse

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.

Sonstige Hinweise

Due to license agreement restrictions, this product cannot be purchased for resale.

Rechtliche Hinweise

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Kristin Hochweller et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(13), 5931-5936 (2010-03-17)
Dendritic cells (DCs) are key components of the adaptive immune system contributing to initiation and regulation of T cell responses. T cells continuously scan DCs in lymphoid organs for the presence of foreign antigen. However, little is known about the
Lin Shen et al.
Science signaling, 14(668) (2021-02-04)
The cytoplasmic kinase ZAP70 is critical for T cell antigen receptor (TCR) signaling. The R360P mutation in ZAP70 is responsible for an early-onset familial autoimmune syndrome. The structural location and biochemical signaling effects of the R360P mutation are consistent with
TCR signaling: another Abl-bodied kinase joins the cascade.
Wange, Ronald L
Current Biology, 14, R562-R564 (2004)
Masaki Matsumoto et al.
Proteomics, 9(13), 3549-3563 (2009-07-18)
Activation of the T-cell receptor (TCR) and that of the B-cell receptor (BCR) elicits tyrosine-phosphorylation of proteins that belongs to similar functional categories, but result in distinct cellular responses. Large-scale analyses providing an overview of the signaling pathways downstream of
Yu Mi Oh et al.
Nature communications, 6, 8698-8698 (2015-10-29)
Induction of T-cell clonal anergy involves serial activation of transcription factors, including NFAT and Egr2/3. However, downstream effector mechanisms of these transcription factors are not fully understood yet. Here we identify Ndrg1 as an anergy factor induced by Egr2. Ndrg1

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