05-502
Anti-FRS2/SNT-1 Antibody
Upstate®, from mouse
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About This Item
UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Biologische Quelle
mouse
Qualitätsniveau
Antikörperform
purified antibody
Antikörper-Produkttyp
primary antibodies
Klon
monoclonal
Speziesreaktivität
rat, human
Hersteller/Markenname
Upstate®
Methode(n)
immunoprecipitation (IP): suitable
western blot: suitable
Isotyp
IgG
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... FRS2(10818)
Spezifität
FRS2/SNT-1 in unstimulated cells and phosphorylated FRS2/SNT-1 in NGF-stimulated cells
Immunogen
Peptide corresponding to residues 283-297 of human FRS2/SNT-1
Anwendung
Research Category
Zelluläre Signaltransduktion
Zelluläre Signaltransduktion
Research Sub Category
Entwicklungsabhängige Signalübertragung
Entwicklungsabhängige Signalübertragung
Detect FRS2/SNT-1 using this Anti-FRS2/SNT-1 Antibody validated for use in IP & WB.
Qualität
routinely evaluated by immunoprecipitating FRS2/SNT-1 from NGF-stimulated and unstimulated rat PC-12 RIPA cell lysates, subsequently immunoblotted with the same antibody.
Zielbeschreibung
non-phosphorylated (68kDa) and phosphorylated (83kDa)
Physikalische Form
Protein G Chromatography
0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide containing 30% glycerol
Format: Purified
Lagerung und Haltbarkeit
2 years at -20°C
Rechtliche Hinweise
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 2
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Human fibroblast growth factor receptor 1-IIIb is a functional fibroblast growth factor receptor expressed in the pancreas and involved in proliferation and movement of pancreatic ductal cells.
Zhanbing Liu, Toshiyuki Ishiwata, Shaxia Zhou, Susanne Maier, Doris Henne-Bruns et al.
Pancreas null
S O Meakin et al.
The Journal of biological chemistry, 274(14), 9861-9870 (1999-03-27)
We have isolated a human cDNA for the signaling adapter molecule FRS-2/suc1-associated neurotrophic factor target and shown that it is tyrosine-phosphorylated in response to nerve growth factor (NGF) stimulation. Importantly, we demonstrate that the phosphotyrosine binding domain of FRS-2 directly
Y R Hadari et al.
Molecular and cellular biology, 18(7), 3966-3973 (1998-06-25)
FRS2 is a lipid-anchored docking protein that plays an important role in linking fibroblast growth factor (FGF) and nerve growth factor receptors with the Ras/mitogen-activated protein (MAP) kinase signaling pathway. In this report, we demonstrate that FRS2 forms a complex
Vito Guagnano et al.
Cancer discovery, 2(12), 1118-1133 (2012-09-25)
Patient stratification biomarkers that enable the translation of cancer genetic knowledge into clinical use are essential for the successful and rapid development of emerging targeted anticancer therapeutics. Here, we describe the identification of patient stratification biomarkers for NVP-BGJ398, a novel
H Xu et al.
The Journal of biological chemistry, 273(29), 17987-17990 (1998-07-11)
Fibroblast growth factors (FGFs) stimulate tyrosine phosphorylation of a membrane-anchored adapter protein, FRS2/SNT-1, promoting its association with Shp-2 tyrosine phosphatase and upstream activators of Ras. Using the yeast two-hybrid protein-protein interaction assay, we show that FRS2/SNT-1 and a newly isolated
Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..
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