860818P

17:0(2S-OH) Ceramide

Avanti Research^™ - A Croda Brand 860818P, powder

• Synonym(e): N-(2′-(S)-hydroxyheptadecanoyl)-D-erythro-sphingosine
• Empirische Formel (Hill-System): C₃₅H₆₉NO₄
• CAS-Nummer: 1246298-47-4
• Molekulargewicht: 567.93
• MDL-Nummer: MFCD22416674
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Form: powder
• Verpackung: pkg of 1 × 5 mg (860818P-5mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand 860818P
• Lipid-Typ: sphingolipids
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@@H](O)CCCCCCCCCCCCCCC)=O)CO
• InChIKey: MBKBHFOACJJHAN-GTQKJTMESA-N

Beschreibung

Allgemeine Beschreibung

Ceramides with 2-hydroxy fatty acids (hFA) group are mainly found in the epidermis.[1] 17:0(2S-OH) Ceramide is a unique ceramide containing 17C long chain base fatty acid (heptadecanoic acid)-with 2′-hydroxyl group in S configuration.[2]

Biochem./physiol. Wirkung

Hydroxy fatty acids (hFA)-sphingolipids helps in cell signaling.[3] They also facilitate cell differentiation and apoptosis.[2] hFA-ceramides in epidermis helps in permeability barrier function. hFA-ceramides are synthesized by fatty acid 2-hydroxylase (FA2H). Mutations of FA2H leads to the development of neurological disorders such as leukodystrophy and spastic paraparesis in humans.[3] hFA-ceramides in the cell membrane are essential for PM02734 drug to exhibit its anti-tumor activity.[4]

Verpackung

5 mL Amber Glass Screw Cap Vial (860818P-5mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3