901776
Poly(OEGMA)
hydrazide functionalized, 25 wt% solution in water
Synonym(e):
PEGMA, POEGMA
Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)
About This Item
Lineare Formel:
[CH2CCH3(COO(CH2CH2O)8CH3)]m[CH2CHCONHNHCO(CH2)4CONHNH2]p
UNSPSC-Code:
12162002
NACRES:
NA.23
Empfohlene Produkte
Form
solution
Mol-Gew.
~20,000 g/mol
Farbe
clear colorless to pale yellow
Funktionelle Gruppe
hydrazide
Lagertemp.
2-8°C
Allgemeine Beschreibung
Poly(oligoethylene glycol methacrylate) (POEGMA), is a comb-shaped, graft copolymer consisting of hydrophilic oligomer PEG chains grafted to a hydrophobic polymethacrylate backbone. POEGMA has been suggested as a viable alternative to poly (ethylene glycol) (PEG) in biological and biomaterial applications. POEGMA has been reported to improve pharmacokinetic properties of protein and peptide conjugates, enhance the stability and gene silencing efficiency of siRNAs, as an anti-fouling surface for biosensors, and eliminate PEG antigenicity. In addition to use in biomolecule-polymer conjugates, PEOGMA has also seen wide spread use in tissue engineering applications, such as hydrogel synthesis. Hydrazide-functionalized POEGMA can be readily used with the corresponding aldehyde-functionalized POEGMA for rapid gelation via reversible hydrazone bond formation. Due to the reversibility of the bond formation and the low viscosity of the precursors, resulting hydrogels can be used as injectable tissue engineering matrices, local drug delivery vehicles for small molecules, or as joint lubricants. In addition, the physical properties of the resulting hydrogels, such as LCST, gelation rates, swelling kinetics, degradation kinetics, and mechanical properties, can all be readily controlled by solution concentration and the ratios of each solution.
Angaben zur Herstellung
This product is provided as a 25 wt% solution in water, ready to be diluted for your specific application. Please see the technical bulletin on the product page for dilution and hydrogel preparation instructions.
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
Besitzen Sie dieses Produkt bereits?
In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Kunden haben sich ebenfalls angesehen
Reactive electro spinning of degradable poly(oligoethylene glycol methacrylate)-based nanofibrous hydrogel networks.
Xu F, et al.
Chemical Communications (Cambridge, England), 52, 1451-1454 (2016)
A. brush-polymer/exendin-4 conjugate reduces blood glucose levels for up to five days and eliminates poly(ethylene glycol) antigenicity.
Qi Y, et al.
Nmr in Biomedicine, 1, 0002-0002 (2016)
A brush-polymer/exendin-4 conjugate reduces blood glucose levels for up to five days and eliminates poly(ethylene glycol) antigenicity.
Qi Y, et al.
Nature Biomedical Engineering, 1, 2-2 (2016)
Weiping Gao et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(36), 15231-15236 (2009-08-27)
The challenge in the synthesis of protein-polymer conjugates for biological applications is to synthesize a stoichiometric (typically 1:1) conjugate of the protein with a monodisperse polymer, with good retention of protein activity, significantly improved pharmacokinetics and increased bioavailability, and hence
Imran Ozer et al.
Biomacromolecules, 18(9), 2699-2710 (2017-08-05)
PEGylation, covalent attachment of PEG to therapeutic biomolecules, in which suboptimal pharmacokinetic profiles limiting their therapeutic utility are of concern, is a widely applied technology. However, this technology has been challenged by reduced bioactivity of biomolecules upon PEGylation and immunogenicity
Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..
Setzen Sie sich mit dem technischen Dienst in Verbindung.