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901422

Sigma-Aldrich

Poly(N-isopropylacrylamid)

average Mn 85,000

Synonym(e):

NIPAM-Polymer, PNIPAM, Polyacrylamid, polyNIPAM

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About This Item

Lineare Formel:
CH3(C6H11NO)nCH3
CAS-Nummer:
25189-55-3
MDL-Nummer:
MFCD00284282
UNSPSC-Code:
12162002
NACRES:
NA.23

Form

crystals

Mol-Gew.

Mn 60,000-110,000 Da by MALLS (GPC)
average Mn 85,000

Farbe

white to off-white

mp (Schmelzpunkt)

96 °C

Lagertemp.

2-8°C

SMILES String

CC(C)NC(=O)C=C

InChI

1S/C6H11NO/c1-3-5-7-6(8)4-2/h4H,2-3,5H2,1H3,(H,7,8)

InChIKey

WDFKEEALECCKTJ-UHFFFAOYSA-N

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Allgemeine Beschreibung

Poly(N-isopropylacrylamide) (PNIPAM) is a temperature-responsive polymer used in biomedical research applications. PNIPAM undergoes a reversible, lower critical solution temperature (LCST) phase transition when heated above 32 °C, transitioning from a soluble to an insoluble material. PNIPAM is also frequently crosslinked to yield hydrogels with reversible, thermal shrinking and swelling. Poly(N-isopropylacrylamide) is also readily functionalized and has been used as the hydrophilic block in the synthesis of thermoresponsive, amphiphilic block copolymers. Due to the similarity in temperature between the LCST of PNIPAM and the temperature of the human body, PNIPAM materials have been frequently utilized in tissue engineering and controlled drug delivery research applications.

Anwendung

Wärmeempfindliches Polymer, das zur Bildung eines Hydrogels verwendet werden kann. Die wässrige Polymerlösung durchläuft einen Phasenübergang von einem löslichen zu einem unlöslichen Zustand, wenn die Temperatur auf etwa 32 °C angehoben wird.
PNIPAM can be used in the formation of a smart hydrogel, which finds potential usage in sensors, fuel cells, supercapacitors, and lithium-ion batteries.[1] It can also be used in the fabrication of molecular nanothermometer.[2] PNIPAM is coated with gold nanoparticles (AuNPs) to form microgels that facilitate highly reproducible signals for surface-enhanced Raman scattering (SERS).[3]

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
MKCJ4783

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Die Dokumentenbibliothek aufrufen

Antti Rahikkala et al.
Biomacromolecules, 16(9), 2750-2756 (2015-07-25)
Thermally responsive hydrogel nanoparticles composed of self-assembled polystyrene-b-poly(N-isopropylacrylamide)-b-polystyrene block copolymers and fluorescent probe 1-anilinonaphthalene-8-sulfonic acid have been prepared by aerosol flow reactor method. We aimed exploring the relationship of intraparticle morphologies, that were, PS spheres and gyroids embedded in PNIPAm
Muhammad Abdul Haq et al.
Materials science & engineering. C, Materials for biological applications, 70(Pt 1), 842-855 (2016-10-25)
Materials which adjust their properties in response to environmental factors such as temperature, pH and ionic strength are rapidly evolving and known as smart materials. Hydrogels formed by smart polymers have various applications. Among the smart polymers, thermoresponsive polymer poly(N-isopropylacrylamide)(PNIPAM)
Nanorod-coated PNIPAM microgels: thermoresponsive optical properties
Karg M, et al.
Small, 3(7), 1222-1229 (2007)
Au@ pNIPAM colloids as molecular traps for surface-enhanced, spectroscopic, ultra-sensitive analysis
Alvarez-Puebla RA, et al.
Angewandte Chemie (International ed. in English), 48(1), 138-143 (2009)
Poly (N-isopropylacrylamide)(PNIPAM) is never hydrophobic
Pelton R, et al.
Journal of Colloid and Interface Science, 348(2), 673-674 (2010)
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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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