Direkt zum Inhalt
Merck

NOTCH1

notch 1

Synonyme:
TAN1, hN1
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(4851) Summary: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008]
  • Mouse(18128) notch 1
  • Rat(25496) notch 1
  • cow(767866) notch 1
  • chicken(395655) notch 1
  • dog(480676) notch 1
  • sheep(101115020) notch 1
  • naked mole-rat(101704336) notch 1
  • domestic cat(101094384) notch 1
  • Horse(100068764) notch 1
  • domestic guinea pig(100724583) notch 1

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

ELISA

Produktnummer
Beschreibung
Spezies
Human Notch-1 ELISA Kit, for serum, plasma, cell culture supernatants and urine,
Spezies
human
Rat Notch-1 ELISA, for serum, plasma and cell culture supernatants,
Spezies
rat

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-Notch 1-Antikörper, NT, serum, from rabbit,
Speziesreaktivität
human, mouse, rat
Anwendung
ELISA
immunohistochemistry

western blot
Anti-NOTCH1 (Cleaved-Val1754) antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
ELISA
immunohistochemistry

western blot
Anti-Notch1 Antibody, Intracellular, serum, from rabbit,
Speziesreaktivität
human
Anwendung
ELISA
immunohistochemistry

western blot
Anti-NOTCH1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Speziesreaktivität
human
Anwendung
immunofluorescence
Anti- Notch1 antibody produced in rabbit, ,
Speziesreaktivität
human, mouse, rat
Anwendung
immunohistochemistry
western blot

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
DAPT, ≥98% (HPLC), solid,
Spezies
mouse, human, rat
L-685,458, >96% (HPLC), solid,
Spezies
mouse, human, rat

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting human NOTCH1,
Spezies
human
MISSION® esiRNA, targeting mouse Notch1,
Spezies
mouse