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Merck

Compounding slow-release capsules: a comprehensive review and an Excel spreadsheet for faster calculations of excipients.

International journal of pharmaceutical compounding (2013-05-01)
Eyal Zur
RÉSUMÉ

Compounding pharmacists throughout the world are compounding a special type of capsule called "slow-release." This type of capsule is a compounding pharmacy application of the commercial hydrophilic matrix tablets. It is a relatively simple system that allows formulating a robust, reliable, and consistent drug system based on 30% w/w to 40% w/w of specific types of hydroxypropyl methylcellulose. The main purpose of these capsules is to attenuate the drug release when there is a clinical need and no commercial medication exists. Five in vitro trials verified and proved this kind of preparation can be compounded by specialized pharmacists achieving substantial attenuation of drug release that resembles the pharmacokinetic profiles of commercial slow-release medications. An in-depth explanation of the mechanism of action of the slow-release capsules is provided. Since the pharmaceutical calculations needed to compound this preparation are time consuming, a suggestion of a faster way to perform these calculations by using a special Excel spreadsheet is provided. The article demonstrates a special table with a comparison between the specifications, results, and conclusions of the five in vitro trials that evaluated the pharmacokinetic rates of compounded slow-release capsules. The regulatory aspect of compounding slow-release capsules is also discussed.

MATÉRIAUX
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Description du produit

Sigma-Aldrich
Methyl cellulose, viscosity: 4,000 cP
Sigma-Aldrich
(Hydroxypropyl)methyl cellulose, viscosity 2,600-5,600 cP, 2 % in H2O(20 °C)(lit.)
Sigma-Aldrich
Methyl cellulose, viscosity: 15 cP, BioReagent, suitable for cell culture
Sigma-Aldrich
Methyl cellulose, viscosity: 1,500 cP
Sigma-Aldrich
(Hydroxypropyl)methyl cellulose
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(Hydroxypropyl)methyl cellulose, viscosity 80-120 cP, 2 % in H2O(20 °C)(lit.)
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(Hydroxypropyl)methyl cellulose, average Mn ~10,000
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(Hydroxypropyl)methyl cellulose, viscosity 40-60 cP, 2 % in H2O(20 °C)(lit.)
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Methyl cellulose, viscosity: 15 cP
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(Hydroxypropyl)methyl cellulose, average Mn ~120,000
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Methyl cellulose, viscosity: 25 cP
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Methyl cellulose, 27.5-31.5% (Methoxyl content), viscosity: 400 cP
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(Hydroxypropyl)methyl cellulose, average Mn ~86,000
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Hypromellose, meets USP testing specifications
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(Hydroxypropyl)methyl cellulose, average Mn ~90,000
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Methyl cellulose, meets USP testing specifications, 26.0-33.0% (methoxyl group, on Dry Basis), viscosity: 400 cP
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Methyl cellulose, 26.0-33.0% (Methoxy group (dry basis)), meets USP testing specifications, viscosity: 1,500 cP
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Methyl cellulose, viscosity 3000-5500 mPa.s, 2 % in H2O(20 °C)
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Methyl cellulose, medium viscosity, Methoxyl content 27.5-31.5 %
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Methyl cellulose, tested according to Ph. Eur.
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Methyl cellulose, 27.5-31.5% methoxyl basis