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1653004

USP

Theophylline

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

1,3-Dimethylxanthine, 2,6-Dihydroxy-1,3-dimethylpurine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione

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About This Item

Formule empirique (notation de Hill):
C7H8N4O2
Numéro CAS:
58-55-9
Poids moléculaire :
180.16
Numéro Beilstein :
13463
Numéro MDL:
MFCD00079619
Code UNSPSC :
41116107
ID de substance PubChem :
329751262
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

theophylline

Fabricant/nom de marque

USP

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

CN1C(=O)N(C)c2[nH]cnc2C1=O

InChI

1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)

Clé InChI

ZFXYFBGIUFBOJW-UHFFFAOYSA-N

Informations sur le gène

human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) , PDE3A(5139) , PDE3B(5140) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144)

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Theophylline USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Aminophylline
  • Aminophylline Delayed-Release Tablets
  • Aminophylline Injection
  • Aminophylline Oral Solution
  • Aminophylline Rectal Solution
  • Aminophylline Tablets
  • Dimenhydrinate

Actions biochimiques/physiologiques

Phosphodiesterase inhibitor; diuretic; cardiac stimulant; muscle relaxant; asthma medication.

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

PHR1151

Theophylline melting point standard, Pharmaceutical Secondary Standard; Certified Reference Material

T0800000

Theophylline, European Pharmacopoeia (EP) Reference Standard

1653117

Theophylline melting point standard, United States Pharmacopeia (USP) Reference Standard

1077708

8-Bromotheophylline, United States Pharmacopeia (USP) Reference Standard

1653048

Theophylline Related Compound D, United States Pharmacopeia (USP) Reference Standard

1653037

Theophylline Related Compound C, United States Pharmacopeia (USP) Reference Standard

1653026

Theophylline Related Compound B, United States Pharmacopeia (USP) Reference Standard

1653060

Theophylline Related Compound F, United States Pharmacopeia (USP) Reference Standard

BP327

Theophylline, British Pharmacopoeia (BP) Reference Standard

PHR2588

Theophylline Related Compound F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2541

Theophylline Related Compound F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2551

Theophylline Related Compound D, Pharmaceutical Secondary Standard; Certified Reference Material

1121038

8-Chlorotheophylline, United States Pharmacopeia (USP) Reference Standard

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Mentions de danger

H301,H360D

Classification des risques

Acute Tox. 3 Oral - Repr. 1B

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Laura López-Cruz et al.
Behavioural brain research, 270, 213-222 (2014-05-27)
Caffeine and theophylline are methylxanthines that are broadly consumed, sometimes at high doses, and act as minor psychostimulants. Both are nonselective adenosine antagonists for A1 and A2A receptors, which are colocalized with dopamine D1 and D2 receptors in striatal areas.
David J Henderson-Smart et al.
The Cochrane database of systematic reviews, (1)(1), CD000273-CD000273 (2010-01-22)
Recurrent apnea is common in preterm infants, particularly at very early gestational ages. These episodes of loss of effective breathing can lead to hypoxemia and bradycardia, which may be severe enough to require resuscitation including use of positive pressure ventilation.
Victoria Boswell-Smith et al.
The Journal of allergy and clinical immunology, 117(6), 1237-1243 (2006-06-06)
Theophylline has been relegated to a second- or even third-line therapy in the treatment of asthma and chronic obstructive pulmonary disease (COPD), behind glucocorticosteroids and beta2-agonists, although recent findings have suggested that theophylline possesses anti-inflammatory and immunomodulatory effects in addition
Diego Caccavo et al.
Molecular pharmaceutics, 12(2), 474-483 (2014-12-17)
In this work the behavior of hydrogel-based matrices, the most widespread systems for oral controlled release of pharmaceuticals, has been mathematically described. In addition, the calculations of the model have been validated against a rich set of experimental data obtained
Amy T Ma et al.
Applied and environmental microbiology, 80(21), 6704-6713 (2014-08-26)
Cyanobacteria are photosynthetic bacteria that are currently being developed as biological production platforms. They derive energy from light and carbon from atmospheric carbon dioxide, and some species can fix atmospheric nitrogen. One advantage of developing cyanobacteria for renewable production of
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