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Astec® CHIROBIOTIC® V2 Chiral (5 μm) HPLC Columns

L × I.D. 25 cm × 21.2 mm, HPLC Column

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About This Item

Code UNSPSC :
41115700
eCl@ss :
32110501
Nomenclature NACRES :
SB.52

product name

Astec® Chirobiotic® V2 Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 21.2 mm

Matériaux

stainless steel column

Niveau de qualité

Agence

suitable for USP L88

Description

HPLC column

Gamme de produits

Astec®

Conditionnement

pkg of 1 ea

Fabricant/nom de marque

Astec®

Paramètres

0-45 °C temperature
241 bar pressure (3500 psi)

Technique(s)

HPLC: suitable
LC/MS: suitable

L × D.I.

25 cm × 21.2 mm

Matrice

High-purity silica gel particle platform
fully porous particle

Groupe de la matrice active

vancomycin phase

Taille des particules

5 μm

Dimension de pores

200 Å

operating pH range

3.5-7.0

Technique de séparation

chiral

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Description générale

Neutral molecules, amides, acids, esters and amines show considerable enantioselectivity on these vancomycin-based CSPs. A wide variety of secondary and tertiary amines have been separated on the CHIROBIOTIC® V in the polar ionic mode. The CHIROBIOTIC® V has demonstrated many of the separation characteristics of protein-based stationary phases, but with exceptional stability and much higher sample capacity. Some chiral analytes have been resolved that have not been reported separated on any other chiral stationary phase. CHIROBIOTIC® V and V2 differ in their bonding chemistry the pore size of the support particle, giving them different selectivity and preparative capacity.

  • Bonded phase: Vancomycin
  • Operating pH range: 3.5 - 7.0
  • Particle diameter: 5, 10 or 16 μm
  • Pore size: 100 Å (CHIROBIOTIC® V) or 200 Å (CHIROBIOTIC® V2)

CHIROBIOTIC FAQs
CHIROBIOTIC Reference Bibliography
Chiral Product Literature

Application


  • Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-threo-methylphenidate, d,l-threo-ethylphenidate and d,l-threo-ritalinic acid in rat plasma and its application to pharmacokinetic study.: This study utilizes the Astec® CHIROBIOTIC® V2 Chiral HPLC Column to develop and validate a UFLC-MS/MS method for the enantioselective determination of various methylphenidate and ritalinic acid enantiomers in rat plasma. The column′s application in pharmacokinetic studies underscores its effectiveness in biomedical research, particularly in analyzing chiral drug molecules (Zhang et al., 2016).

  • New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase.: This research employs the Astec® CHIROBIOTIC® V2 Chiral HPLC Column for the chiral separation and determination of warfarin enantiomers. The study highlights the column′s utility in pharmaceutical analysis and its effectiveness in the study of chiral drug enantiomers (Malakova et al., 2009).


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Informations légales

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC

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Certificats d'analyse (COA)

Lot/Batch Number

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Chromatography Liquid Chiral Separations
Xiao, T.L., et al.
Encyclopedia of Separation Science, 1-15 (2000)
Doris Frühauf et al.
Journal of chromatography. A, 1269, 242-254 (2012-10-30)
A sub-minute enantioselective normal phase high performance liquid chromatographic (HPLC) method for the analysis of a chiral precursor molecule employed frequently in folic acid syntheses was developed, optimized and successfully validated according to ICH-guidelines. It could be shown that ultra-high
New chemo-enzymatic approaches for the synthesis of (R)- and (S)-bufuralol
Nagy, Botond, et al.
Tetrahedron Asymmetry, 25 (18-19), 1316-1322 (2014)
Validation of a chiral liquid chromatography?tandem mass spectrometry method for the determination of pantoprazole in dog plasma
Chen, Meixia, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 906, 85-90 (2012)
Enantioselective and sensitive determination of carvedilol in human plasma using chiral stationary-phase column and reverse-phase liquid chromatography with tandem mass spectrometry
Jiang, Juanjuan, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 960, 92-97 (2014)

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