SRP6508
Haptoglobin (Phenotype 2-2) from human plasma
≥95% (SDS-PAGE)
Synonyme(s) :
Hp 2-2
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32
Produits recommandés
Description générale
Haptoglobin(Hp) is an acute-phase antioxidant, found abundantly in the plasma , and it exhibits genetic polymorphism, that results in three genotypes namely Hp 1-1, Hp 1-2, and Hp 2-2. The HP gene is mapped on the human chromosome at16q22.2.
Application
Haptoglobin(Phenotype 2-2) from human plasma has been used as a mature form of haptoglobinto study its effects on human liver cancer cells. It has also been used inthe preparation of the radiolabeled haptoglobin-hemoglobin (Hp-Hb) complex.
Actions biochimiques/physiologiques
Haptoglobin (Hp)binds to the extra corpuscular hemoglobin in the plasma to avoid iron-mediatedoxidative tissue damage. Haptoglobin2-2 (Hp 2-2) is the least effective of the three haptoglobin phenotypes inbinding free hemoglobin and therefore provides less antioxidant benefits thanHp 1-1. Hp 2-2 is associated with renal failure, familial and post-traumatic epilepsy. It isalso associated with hypertension, atherosclerosis, and coronary heart diseasesin patients with type II diabetes. Individuals who are phenotype 2-2 have the lowest concentration ofhaptoglobin in plasma.
Forme physique
Lyophilized as a salt-free solid.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
The Haptoglobin 2-2 Phenotype Affects Serum Markers of Iron Status in Healthy Males
Michel R L, et al.
Clinical Chemistry, 46, 1619?1625-1619?1625 (2000)
The haptoglobin 2-2 genotype is associated with inflammation and carotid artery intima-media thickness
Rinkoo D, et al.
Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease, 13(5), 373?376-373?376 (2016)
Haptoglobin 2-2 genotype determines chronic vasospasm after experimental subarachnoid hemorrhage
Chaichana K, et al.
Stroke, 38(12), 3266-3271 (2007)
Seasonal Childhood Anaemia in West Africa Is Associated with the Haptoglobin 2-2 Genotype
Atkinson S, et al.
PLoS Medicine, 3(5), e172-e172 (2006)
Trans-ethnic predicted expression genome-wide association analysis identifies a gene for estrogen receptor-negative breast cancer
Guimin G, et al.
PLoS Genetics (2017)
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique