SML0945

Nilvadipine

≥98% (HPLC)

• Synonyme(s) : 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester, 5-Isopropyl-3-methyl-2-cyano-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate, FK-235, FR-34235, Isopropyl 6-cyano-5-methoxycarbonyl-2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate, Nivadipine, Nivaldipine, SKF-102362
• Formule empirique (notation de Hill): C₁₉H₁₉N₃O₆
• Numéro CAS: 75530-68-6
• Poids moléculaire : 385.37
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 15 mg/mL, clear
• Température de stockage: room temp
• InChI: 1S/C19H19N3O6/c1-10(2)28-19(24)15-11(3)21-14(9-20)17(18(23)27-4)16(15)12-6-5-7-13(8-12)22(25)26/h5-8,10,16,21H,1-4H3
• Clé InChI: FAIIFDPAEUKBEP-UHFFFAOYSA-N

Description

Description générale

Nilvadipine is a dihydropyridine drug.

Actions biochimiques/physiologiques

Nilvadipine is a potent calcium channel blocker that is used for treatment of hypertension. Nilvadipine, as other dihydropyridine calcium antagonists, decreases intracellular calcium concentration causing dilation of the coronary and systemic arteries. Nilvadipine acutely reduced brain Aβ levels in a transgenic mouse model of Alzheimer′s disease (AD).

Nilvadipine, apart from its antihypertensive effect, is known to decrease the accumulation of β-amyloid protein in the brain. Therefore, it is effective in the treatment of Alzheimer′s disease. Nilvadipine also promotes cognitive function in hypertensive patients.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable