SML0120

Perhexiline maleate salt

≥98% (HPLC)

• Synonyme(s) : 2-(2,2-Dicyclohexylethyl)piperidine
• Formule empirique (notation de Hill): C₁₉H₃₅N · C₄H₄O₄
• Numéro CAS: 6724-53-4
• Poids moléculaire : 393.56
• Numéro CE : 229-775-5
• Numéro MDL: MFCD00057329
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825171
• Nomenclature NACRES : NA.25

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to tan
• Solubilité: DMSO: ≥5 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: OC(=O)\C=C/C(O)=O.C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3
• InChI: 1S/C19H35N.C4H4O4/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18;5-3(6)1-2-4(7)8/h16-20H,1-15H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
• Clé InChI: JDZOTSLZMQDFLG-BTJKTKAUSA-N
• Informations sur le gène: human ... CPT1B(1375) , CPT2(1376) , MTOR(2475)

Description

Description générale

Perhexiline maleate regulates coronary vasodilatation and blocks exercise-induced tachycardia. It is used to treat angina pectoris and variant angina. Perhexiline maleate functions as a cardiac metabolic agent. It is associated with peripheral neuropathy, high intracranial pressure with papilledema and proximal myopathy.

Application

Perhexiline maleate salt has been used as a stock for worm lifespan assay. It has also been used to block fatty acid oxidation.

Perhexiline maleate salt has been used to block fatty acid oxidation. It has also been used as 5′ adenosine monophosphate-activated protein kinase (AMPK) activator and in worm lifespan assay.

Actions biochimiques/physiologiques

Perhexiline maleate is an anti-anginal metabolic modulator. It inhibits the mitochondrial enzyme carnitine palmitoyltransferase CPT-1 and to a lesser extent CPT-2. This causes a shift in myocardial substrate utilisation from long chain fatty acids to carbohydrates, resulting in increased glucose and lactate utilization and increased ATP production for the same O2 consumption as before and consequently increases myocardial efficiency. Perhexiline maleate was also recently found to inhibit the activity of mTORC1.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable