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SBR00032

Sigma-Aldrich

MIT HCl Ready Made Solution

95 mg/mL in water (9.5%)

Synonyme(s) :

2-Methyl-1,2-thiazol-3-one hydrochloride, Methylisothiazolinone hydrochloride

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About This Item

Code UNSPSC :
51102829
Nomenclature NACRES :
NA.76

Forme

liquid

Niveau de qualité

200

Concentration

95 mg/mL in water (9.5%)

Mode d’action

protein synthesis | interferes

Température de stockage

2-8°C

InChI

1S/C4H5NOS.ClH/c1-5-4(6)2-3-7-5;/h2-3H,1H3;1H

Clé InChI

SJXPQSRCFCPWQQ-UHFFFAOYSA-N

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Description générale

Methylisothiazolinone, also known as 2-Methyl-4-isothiazolin-3-one, belongs to the group of isothiazolinones. 2-Methyl-4-isothiazolin-3-one is utilized in microbiology and cell biology applications to effectively prevent the growth of bacterial contaminants, ensuring the purity of cell lines.

Application

Methylisothiazolinone (MIT) has been used:
  • in research on the effects of the N-methyl D-aspartate (NMDA) receptor antagonist kynurenic acid on human cortical development [1]
  • as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and role in apoptotic cell death(2)
  • to research the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites(3)

Caractéristiques et avantages

  • Ready available solution reduce the need for preparation time
  • Commonly used in Cell Biology and Biochemical applications
  • High quality antibiotic suitable for mulitple research applications

Autres remarques

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Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

CorrosionExclamation markEnvironment
GHS05,GHS07,GHS09

Mention d'avertissement

Danger

Mentions de danger

H302,H314,H317,H411

Classification des risques

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1A - Skin Sens. 1

Risques supp

EUH071

Code de la classe de stockage

8B - Non-combustible corrosive hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
0000331988
0000320592
0000320591
0000322710

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Eun-Jung Park et al.
Toxicology in vitro : an international journal published in association with BIBRA, 62, 104661-104661 (2019-10-21)
Methylisothiazolinone (MIT) has been used in wide spectrum of fields due to its ability to inhibit microbial proliferation with low toxicity. Meanwhile, in Korea, the concern about the hazardous effects of MIT was amplified by the occurrence of patients that
Shen Du et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(17), 7408-7416 (2002-08-28)
Neurodegenerative disorders in humans may be triggered or exacerbated by exposure to occupational or environmental agents. Here, we show that a brief exposure to methylisothiazolinone, a widely used industrial and household biocide, is highly toxic to cultured neurons but not
Zhengxi Wei et al.
Toxicology letters, 338, 67-77 (2020-12-09)
Chemical-peptide conjugation is the molecular initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatography/ultraviolet (HPLC/UV) detection method to quantify chemical-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two synthetic
Erol Capkin et al.
Chemosphere, 182, 720-729 (2017-05-23)
Triclosan (TRC), chloroxylenol (PCMX) and methylisothiazolinone (MIT) have been commonly used as an antimicrobial in soaps while borax (BRX) is used in household cleaning. After using these chemicals, they are washed down drains and getting into the aquatic ecosystem in
M D Lundov et al.
The British journal of dermatology, 165(6), 1178-1182 (2011-07-23)
In the early 2000s the preservative methylisothiazolinone (MI) was released as an individual preservative for industrial products and, in 2005, it was permitted for use in cosmetic products. Up until then MI had been used only in combination with methylchloroisothiazolinone
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