SAB4504094

Anti-phospho-p38 MAPK (pTyr³²²) antibody produced in rabbit

affinity isolated antibody

• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen 41 kDa
• Espèces réactives: mouse, rat, human
• Concentration: ~1 mg/mL
• Technique(s): ELISA: 1:5000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• Numéro d'accès NCBI: Q16539
• Numéro d'accès UniProt: Q16539
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: phosphorylation (pTyr322)
• Informations sur le gène: human ... MAPK14(1432)

Description

Description générale

MAPK14 (mitogen-activated protein kinase 14) is a Ser/Thr kinase made of 90 to 360 residues. p38αMAPK is ubiquitously expressed. It is found in the cytosol, but it can translocate to the nucleus. This gene is located on human chromosome 6p21.31.

Immunogène

The antiserum was produced against synthesized peptide derived from human p38 MAPK around the phosphorylation site of Tyr322.

Immunogen Range: 288-337

Actions biochimiques/physiologiques

MAPK14 (mitogen-activated protein kinase 14) participates in resistance of colon cancer cells to camptothecin-related drugs. This protein is required for the growth of embryos. This gene controls proliferation, differentiation, cell death, adhesion, migration, as well as the response to stress and many metabolic pathways. Polymorphism in MAPK14/p38a leads to deletion or overproduction of myelosuppressive cytokines and result in certain bone marrow failure syndromes.

Caractéristiques et avantages

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Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable