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Key Documents

SAB4502966

Sigma-Aldrich

Anti-Tyrosine Hydroxylase, N-Terminal antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

TH isoform 3, TH isoform a, TH-4, TY3H, TYH

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 58 kDa

Espèces réactives

rat, mouse, human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Numéro d'accès NCBI

P07101

Numéro d'accès UniProt

P07101

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... TH(7054)

Catégories apparentées

Description générale

Anti-Tyrosine Hydroxylase Antibody detects endogenous levels of total Tyrosine Hydroxylase protein.
The TH (tyrosine Hydroxylase) gene codes for a homotetramer that contains catalytic, regulatory, and tetramerization domains in each of its subunit.

Immunogène

The antiserum was produced against synthesized peptide derived from human Tyrosine Hydroxylase.

Immunogen Range: 41-90

Application

Anti-Tyrosine Hydroxylase, N-Terminal antibody produced in rabbit has ben used in immunohistochemistry.

Actions biochimiques/physiologiques

The conversion of l-tyrosine into l-DOPA (L-3,4-dihydroxyphenylalanine) is catalyzed by tyrosine hydroxylase (TH), which is the rate-limiting step in the in the synthesis of catecholamines such as dopamine and also other necessary hormones and neuromodulators. The TH enzyme deficiency results in low levels of dopamine, which is characterised in Parkinson′s disease.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Adrenergic regulation during acute hepatic infection with Entamoeba histolytica in the hamster: involvement of oxidative stress, Nrf2 and NF-KappaB.
Aldaba-Muruato LR
Parasite (Paris, France), 24:46, 1-13 (2017)
Molecular Mechanism of Regulation of MTA1 Expression by Granulocyte Colony-stimulating Factor.
Kumar AS
The Journal of Biological Chemistry, 291(23), 12310-12321 (2016)
Regulation of tyrosine hydroxylase is preserved across different homo- and heterodimeric 14-3-3 proteins.
Ghorbani S
Amino Acids, 48(5), 1221-1229 (2016)
Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules.
Jorge-Finnigan A
The Journal of Biological Chemistry, 292(34), 14092-14107 (2017)
Izel Tekin et al.
Parkinsonism & related disorders, 23, 86-90 (2016-01-07)
Many of the symptoms and signs of Parkinson's disease (PD) arise from the death of midbrain dopamine neurons that utilize tyrosine hydroxylase (TH) as the rate-limiting enzyme in catecholamine biosynthesis. We investigated whether the presence of a common TH polymorphism
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