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Key Documents

SAB4502022

Sigma-Aldrich

Anti-NOTCH2 (Cleaved-Val1697) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

Motch B, NOTC2, NOTCH2, NTC2, Neurogenic locus notch homolog protein 2 precursor

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 83 kDa

Espèces réactives

human, rat, mouse

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:10000
western blot: 1:500-1:1000

Numéro d'accès NCBI

Q04721

Numéro d'accès UniProt

Q04721

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

proteolytically cleaved (Val1697)

Informations sur le gène

human ... NOTCH2(4853)

Catégories apparentées

Description générale

Anti-NOTCH2 (Cleaved-Val1697) antibody detects endogenous levels of fragment of activated NOTCH2 (Cleaved-Val1697) protein.

Immunogène

The antiserum was produced against synthesized peptide derived from human NOTCH2.

Immunogen Range: 1678-1727

Actions biochimiques/physiologiques

The NOTCH2 gene is known to be involved in the proliferation, cell cycle progression and colony formation of cancer cells. Upregulation of the gene is observed in hepatocellular carcinoma and salivary adenoid cystic carcinoma. Deletion of NOTCH2 increases the sensitivity of the cancer cells to chemotherapeutic agents such as 5-fluorouracil. NOTCH2 plays an important role in the regulation of liver development.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Michela Colombo et al.
Haematologica, 105(7), 1925-1936 (2019-10-05)
Multiple myeloma is still incurable due to an intrinsic aggressiveness or, more frequently, to the interactions of malignant plasma cells with the bone marrow (BM) microenvironment. Myeloma cells educate BM cells to support neoplastic cell growth, survival, acquisition of drug
Domenica Giannandrea et al.
Haematologica, 107(9), 2183-2194 (2022-03-11)
Multiple myeloma (MM) is an incurable hematologic neoplasm, whose poor prognosis is deeply affected by the propensity of tumor cells to localize in the bone marrow (BM) and induce the protumorigenic activity of normal BM cells, leading to events associated
Wen-Rui Wu et al.
Oncology reports, 36(1), 181-188 (2016-05-26)
The Notch pathway plays an important role in both stem cell biology and cancer. Notch2 was reported to be upregulated in human hepatocellular carcinoma (HCC) tissues. However, the biological function of Notch2 in human HCC cells has not yet been
Giuseppina Catanzaro et al.
International journal of molecular sciences, 18(12) (2017-12-21)
The mechanisms by which microRNAs control pediatric high-grade gliomas (pHGGs) have yet to be fully elucidated. Our studies of patient-derived pHGG tissues and of the pHGG cell line KNS42 revealed down-regulation in these tumors of three microRNAs, specifically miR-107, miR-181c
Kai Dai et al.
Frontiers in immunology, 8, 320-320 (2017-04-07)
The mechanisms by which tumor-responsive CD8+ T cells are regulated are important for understanding the tumor immunity and for developing new therapeutic strategies. In current study, we identified the expression of 1810011o10 Rik, which is the homolog of human thyroid
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