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Key Documents

SAB1400673

Sigma-Aldrich

Anti-NXN antibody produced in mouse

IgG fraction of antiserum, buffered aqueous solution

Synonyme(s) :

Anti-FLJ12614, Anti-TRG-4

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

IgG fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human

Technique(s)

immunofluorescence: suitable
western blot: 1 μg/mL

Numéro d'accès UniProt

Q6DKJ4

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... NXN(64359)

Description générale

NXN (Nucleoredoxin) is a novel cell growth regulatory protein belonging to the thioredoxin (TRX) family. It has a molecular mass of 55kDa. It is expressed in several adult tissues and is predominantly localized in the nucleus. It consists of a conserved TRX domain and a catalytic region, which exerts oxidoreductase activity.

Immunogène

NXN (NP_071908, 1 a.a. ~ 435 a.a) full-length human protein.

Sequence
MSGFLEELLGEKLVTGGGEEVDVHSLGARGISLLGLYFGCSLSAPCAQLSASLAAFYGRLRGDAAAGPGPGAGAGAAAEPEPRRRLEIVFVSSDQDQRQWQDFVRDMPWLALPYKEKHRKLKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIAGPLLRNNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSEESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDEDCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYKAKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEAFVNDFLAEKLKPEPI

Actions biochimiques/physiologiques

NXN (Nucleoredoxin) is associated with several regulatory cellular processes such as regulation of Wnt/β-catenin pathway, oxidative stress responses. It acts as a thiol reductase and reactive oxygen species regulator during thiol-mediated oxidoreduction process. NXN possesses specific binding affinity for protein phosphatase 2A (PP2A). It interacts directly to the catalytic subunit of PP2A during phosphatase activity. It has also been reported that NXN may be involved in the transcriptional regulation of NF-κβ, AP-1, and CREB activation in HEK293 cells.

Forme physique

Solution in phosphate buffered saline, pH 7.4

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

H Kurooka et al.
Genomics, 39(3), 331-339 (1997-02-01)
In a yeast artificial chromosome contig close to the nude locus on mouse chromosome 11, we identified a novel gene, nucleoredoxin, that encodes a protein with similarity to the active site of thioredoxins. Nucleoredoxin is conserved between mammalian species, and
Yosuke Funato et al.
Antioxidants & redox signaling, 9(8), 1035-1057 (2007-06-15)
Thioredoxin (TRX) family proteins are involved in various biologic processes by regulating the response to oxidative stress. Nucleoredoxin (NRX), a relatively uncharacterized member of the TRX family protein, has recently been reported to regulate the Wnt/beta-catenin pathway, which itself regulates
K Hirota et al.
Biochemical and biophysical research communications, 274(1), 177-182 (2000-07-25)
Well-established mechanisms for regulation of protein activity include thiol-mediated oxidoreduction in addition to protein-protein interactions and phosphorylation. Nucleoredoxin (NRX), glutaredoxin (GRX), and thioredoxin (TRX) have been shown to act as a potent thiol reductase and reactive oxygen species regulator. They
Katarzyna Lechward et al.
FEBS letters, 580(15), 3631-3637 (2006-06-13)
A trimeric protein phosphatase 2A (PP2A(T55)) composed of the catalytic (PP2Ac), structural (PR65/A), and regulatory (PR55/B) subunits was isolated from rabbit skeletal muscle by thiophosphorylase affinity chromatography, and contained two additional proteins of 54 and 55 kDa, respectively. The 54

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