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S166

Sigma-Aldrich

Saclofen

solid

Synonyme(s) :

β-(Aminomethyl)-4-chlorobenzeneethanesulfonic acid

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About This Item

Formule empirique (notation de Hill):
C9H12ClNO3S
Numéro CAS:
125464-42-8
Poids moléculaire :
249.71
Numéro MDL:
MFCD00216817
Code UNSPSC :
51111800
ID de substance PubChem :
329824485
Nomenclature NACRES :
NA.32

Forme

solid

Niveau de qualité

200

Couleur

white

Solubilité

0.1 M NaOH: 20 mg/mL

Chaîne SMILES 

NCC(CS(O)(=O)=O)c1ccc(Cl)cc1

InChI

1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)

Clé InChI

JYLNVJYYQQXNEK-UHFFFAOYSA-N

Informations sur le gène

human ... GABBR1(2550) , GABBR2(9568)
mouse ... GABBR1(54393) , GABBR2(242425)
rat ... GABBR1(81657) , GABBR2(83633)

Application

Saclofen has been used as a GABAB receptor antagonist to study the analgesic effect of repeated injections of oxycodone in rats.
Saclofen has been used to prevent the inhibitory action of oxytocin on capsaicin-induced glutamatergic spontaneous excitatory transmission in rat neurons.

Actions biochimiques/physiologiques

Saclofen is the sulphonic analog of baclofen and is a selective GABAB receptor antagonist.
Saclofen might possess sympathetic nervous system-dependent anti-inflammatory action.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Cord Blood-Derived Neurons Are Originated from CD133+/CD34 Stem/Progenitor Cells in a Cell-to-Cell Contact Dependent Manner
Vincent Z
Stem Cells and Development (2005)
Gabriel S Bassi et al.
Naunyn-Schmiedeberg's archives of pharmacology, 389(8), 851-861 (2016-04-24)
Recent studies have demonstrated that the central nervous system controls inflammatory responses by activating complex efferent neuroimmune pathways. The present study was designed to evaluate the role that central gamma-aminobutyric acid type B (GABA-B) receptor plays in neutrophil migration in
Faraz Mahdian Dehkordi et al.
The Korean journal of pain, 32(3), 160-167 (2019-07-02)
Pain is a complex mechanism which involves different systems, including the opioidergic and GABAergic systems. Due to the side effects of chemical analgesic agents, attention toward natural agents have been increased. Artemisinin is an herbal compound with widespread modern and
N Bowery
Trends in pharmacological sciences, 10(10), 401-407 (1989-10-01)
Much progress has been made in GABAB receptor pharmacology since the discovery of this receptor in 1980. Selective agonists and antagonists have been developed and a functional role for the receptor as a mediator of slow inhibitory postsynaptic potentials in
Mahinda Kommalage et al.
European journal of pharmacology, 525(1-3), 69-73 (2005-11-22)
It has been shown that analgesics such as morphine, lidocaine and clonidine increase the release of spinal acetylcholine. Acetylcholine may therefore play an important role in the regulation of spinal pain threshold. Since behavioral as well as in vitro studies
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